3D Printing Biocompatible Polymers for Biomedical Applications

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Description
Since their invention in the 19th century, polymers have played an essential role, yet their full potential in biomedicine remains largely untapped. Biocompatible polymers, known for their flexibility, accessibility, and modifiability, hold promise in creating complex biomimetic structures for bioscaffolds

Since their invention in the 19th century, polymers have played an essential role, yet their full potential in biomedicine remains largely untapped. Biocompatible polymers, known for their flexibility, accessibility, and modifiability, hold promise in creating complex biomimetic structures for bioscaffolds and biosensors. 3D printing, an emerging manufacturing technique, enables on-demand production of intricate structures, offering significant potential for personalized medicine and advanced biomedical engineering. This thesis focuses on designing and developing polymer-based bioscaffolds and biosensors using 3D printing. Chapter 1 provides an all-round introduction to common 3D printing techniques and polymeric biomaterials, especially biodegradable polymers. In Chapter 2, a gill-mimicking thermoelectric generator (TEG) was created to harvest body temperature and monitor bio-signals without external power. The out-of-plane geometry is obtained with fused deposition modeling (FDM), which is crucial for effective contact with various curved surfaces. Further improvements in biocompatibility enable the material to be implanted in vivo. Chapter 3 discusses UV-facilitated DIW printing for pelvic organ prolapse (POP) tissue scaffolds, featuring crosslink strategies for native tissue-like mechanical behavior. The double network comprises thiol-ene UV-initiated chemical bonds and alkaline-induced crystal regions as physical crosslink nodes. The crosslink density affects the degradation rate of the scaffold, enabling a slow degradation behavior beneficial to the recovery of the injured tissue. Chapter 4 presents a novel artificial artery design with varying moduli and natural polymers for bypass surgeries. The inner and outer layers of the conduit were stretched successively under different strains, endowing the vessel with varying moduli. Natural polymers were utilized to achieve low cytotoxicity and promote adequate cell adhesion. Additionally, the gelation behavior and the ink composition suitable for extrusion with a DIW platform were thoroughly studied. Image analysis, finite element analysis, and machine learning were employed to substantiate the findings regarding mechanical properties, extrusion quality, and printing fidelity in Chapters 3 and 4. This combination of computer-assisted analysis with experimental results enhances the robustness of the studies. Lastly, Chapter 5 provides an outlook and perspectives on the applications of biocompatible polymeric materials manufactured by 3D printing in the field of health applications.
Date Created
2024
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Multiphase Direct Ink Writing: Nature-Inspired Layer Patterning For Structural and Functional Versatility

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Description
Additive manufacturing, also known as 3D printing, has revolutionized modern manufacturing in several key areas: complex geometry fabrication, rapid prototyping and iteration, customization and personalization, reduced material waste, supply chain flexibility, complex assemblies and consolidated parts, and material innovation. As

Additive manufacturing, also known as 3D printing, has revolutionized modern manufacturing in several key areas: complex geometry fabrication, rapid prototyping and iteration, customization and personalization, reduced material waste, supply chain flexibility, complex assemblies and consolidated parts, and material innovation. As the technology continues to evolve, its impact on manufacturing is expected to grow, driving further innovation and reshaping traditional production processes. Some innovation examples in this field are inspired by natural or bio-systems, such as honeycomb structures for internal morphological control to increase strength, bio-mimetic composites for scaffold structures, or shape memory materials in 4D printing for targeted drug delivery. However, the technology is limited by its ability to manipulate multiple materials, especially tuning their submicron characteristics when they show non-compatible chemical or physical features. For example, the deposition and patterning of nanoparticles with different dimensions have seen little success, except in highly precise and slow 3D printing processes like aerojet or electrohydrodynamic. Taking inspiration from the layered patterns and structures found in nature, this research aims to demonstrate the development and versatility of a newly developed ink-based composite 3D printing mechanism called multiphase direct ink writing (MDIW). The MDIW is a multi-materials extrusion system, with a unique nozzle design that can accommodate two immiscible and non-compatible polymer or nano-composite solutions as feedstock. The intricate internal structure of the nozzle enables the rearrangement of the feedstock in alternating layers (i.e., ABAB...) and multiplied within each printed line. This research will first highlight the design and development of the MDIW 3D printing mechanism, followed by laminate processing to establish the requirements of layer formation in the XY-axis and the effect of layer formation on its microstructural and mechanical properties. Next, the versatility of the mechanism is also shown through the one-step fabrication of shape memory polymers with dual stimuli responsiveness, highlighting the 4D printing capabilities. Moreover, the MDIW's capability of dual nanoparticle patterning for manufacturing multi-functional carbon-carbon composites will be highlighted. Comprehensive and in-depth studies are conducted to investigate the morphology-structure-property relationships, demonstrating potential applications in structural engineering, smart and intelligent devices, miniature robotics, and high-temperature systems.
Date Created
2024
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Rapid 3D Printing of Reduced Graphene Oxide/Polymer Composites Using Micro-Continuous Liquid Interface Production

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Description
Integrating advanced materials with innovative manufacturing techniques has propelled the field of additive manufacturing into new frontiers. This study explores the rapid 3D printing of reduced graphene oxide/polymer composites using Micro-Continuous Liquid Interface Production (μCLIP), a cutting-edge technology known for

Integrating advanced materials with innovative manufacturing techniques has propelled the field of additive manufacturing into new frontiers. This study explores the rapid 3D printing of reduced graphene oxide/polymer composites using Micro-Continuous Liquid Interface Production (μCLIP), a cutting-edge technology known for its speed and precision. A printable ink is formulated with reduced graphene oxide for μCLIP-based 3D printing. The research focuses on optimizing μCLIP parameters to fabricate reduced graphene composites efficiently. The study encompasses material synthesis, ink formulation and explores the resulting material's structural and electrical properties. The marriage of graphene's unique attributes with the rapid prototyping capabilities of μCLIP opens new avenues for scalable and rapid production in applications such as energy storage, sensors, and lightweight structural components. This work contributes to the evolving landscape of advanced materials and additive manufacturing, offering insights into the synthesis, characterization, and potential applications of 3D printed reduced graphene oxide/polymercomposites.
Date Created
2024
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Direct Ink Written Luminous Monoliths for Hydrogen Sulfide Photocatalysis

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Description
The conversion of H2S enables the recycling of a waste gas into a potential source of hydrogen at a lower thermodynamic energy cost as compared to water splitting. However, studies on the photocatalytic decomposition of H2S focus on traditional deployment

The conversion of H2S enables the recycling of a waste gas into a potential source of hydrogen at a lower thermodynamic energy cost as compared to water splitting. However, studies on the photocatalytic decomposition of H2S focus on traditional deployment of catalyst materials to facilitate this conversion, and operation only when a light source is available. In this study, the efficacy of Direct Ink Written (DIW) luminous structures for H2S conversion has been investigated, with the primary objective of sustaining H2S conversion when a light source has been terminated. Additionally, as a secondary objective, improving light distribution within monoliths for photocatalytic applications is desired. The intrinsic illumination of the 3D printed monoliths developed in this work could serve as an alternative to monolith systems that employ light transmitting fiber optic cables that have been previously proposed to improve light distribution in photocatalytic systems. The results that were obtained demonstrate that H2S favorable adsorbents, a wavelength compatible long afterglow phosphor, and a photocatalyst can form viscoelastic inks that are printable into DIW luminous monolithic contactors. Additionally, rheological, optical and porosity analyses conducted, provide design guidelines for future studies seeking to develop DIW luminous monoliths from compatible catalyst-phosphor pairs. The monoliths that were developed demonstrate not only improved conversion when exposed to light, but more significantly, extended H2S conversion from the afterglow of the monoliths when an external light source was removed. Lastly, considering growing interests in attaining a global circular economy, the techno-economic feasibility of a H2S-CO2 co-utilization plant leveraging hydrogen from H2S photocatalysis as a feed source for a downstream CO2 methanation plant has been assessed. The work provides preliminary information to guide future chemical kinetic design characteristics that are important to strive for if using H2S as a source of hydrogen in a CO2 methanation facility.
Date Created
2023
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Data-Driven Approaches for Fatigue Prediction of Additively Manufactured Ti-6AL-4V and Simulation of Surface Defect Effect on Pipelines

Description
The study aims to develop and evaluate failure prediction models that accurately predict crack initiation sites, fatigue life in additively manufactured Ti-6Al-4V, and burst pressure in relevant applications.The first part proposes a classification model to identify crack initiation sites in

The study aims to develop and evaluate failure prediction models that accurately predict crack initiation sites, fatigue life in additively manufactured Ti-6Al-4V, and burst pressure in relevant applications.The first part proposes a classification model to identify crack initiation sites in AM-built Ti-6Al-4V alloy. The model utilizes surface and pore-related parameters and achieves high accuracy (0.97) and robustness (F1 score of 0.98). Leveraging CT images for characterization and data extraction from the CT-images built STL files, the model effectively detects crack initiation sites while minimizing false positives and negatives. Data augmentation techniques, including SMOTE+Tomek Links, are employed to address imbalanced data distributions and improve model performance. This study proposes the Probabilistic Physics-guided Neural Network 2.0 (PPgNN) for probabilistic fatigue life estimation. The presented approach overcomes the limitations of classical regression machine models commonly used to analyze fatigue data. One key advantage of the proposed method is incorporating known physics constraints, resulting in accurate and physically consistent predictions. The efficacy of the model is demonstrated by training the model with multiple fatigue S-N curve data sets from open literature with relevant morphological data and tested using the data extracted from CT-built STL files. The results illustrate that PPgNN 2.0 is a flexible and robust model for predicting fatigue life and quantifying uncertainties by estimating the mean and standard deviation of the fatigue life. The loss function that trains the proposed model can capture the underlying distribution and reduce the prediction error. A comparison study between the performance of neural network models highlights the benefits of physics-guided learning for fatigue data analysis. The proposed model demonstrates satisfactory learning capacity and generalization, providing accurate fatigue life predictions to unseen examples. An elastic-plastic Finite Element Model (FEM) is developed in the second part to assess pipeline integrity, focusing on burst pressure estimation in high-pressure gas pipelines with interactive corrosion defects. The FEM accurately predicts burst pressure and evaluates the remaining useful life by considering the interaction between corrosion defects and neighboring pits. The FEM outperforms the well-known ASME-B31G method in handling interactive corrosion threats.
Date Created
2023
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Field Driven Design of Graded Cellular Structures

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Description
The design of energy absorbing structures is driven by application specific requirements like the amount of energy to be absorbed, maximum transmitted stress that is permissible, stroke length, and available enclosing space. Cellular structures like foams are commonly leveraged in

The design of energy absorbing structures is driven by application specific requirements like the amount of energy to be absorbed, maximum transmitted stress that is permissible, stroke length, and available enclosing space. Cellular structures like foams are commonly leveraged in nature for energy absorption and have also found use in engineering applications. With the possibility of manufacturing complex cellular shapes using additive manufacturing technologies, there is an opportunity to explore new topologies that improve energy absorption performance. This thesis aims to systematically understand the relationships between four key elements: (i) unit cell topology, (ii) material composition, (iii) relative density, and (iv) fields; and energy absorption behavior, and then leverage this understanding to develop, implement and validate a methodology to design the ideal cellular structure energy absorber. After a review of the literature in the domain of additively manufactured cellular materials for energy absorption, results from quasi-static compression of six cellular structures (hexagonal honeycomb, auxetic and Voronoi lattice, and diamond, Gyroid, and Schwarz-P) manufactured out of AlSi10Mg and Nylon-12. These cellular structures were compared to each other in the context of four design-relevant metrics to understand the influence of cell design on the deformation and failure behavior. Three new and revised metrics for energy absorption were proposed to enable more meaningful comparisons and subsequent design selection. Triply Periodic Minimal Surface (TPMS) structures were found to have the most promising overall performance and formed the basis for the numerical investigation of the effect of fields on the energy absorption performance of TPMS structures. A continuum shell-based methodology was developed to analyze the large deformation behavior of field-driven variable thickness TPMS structures and validated against experimental data. A range of analytical and stochastic fields were then evaluated that modified the TPMS structure, some of which were found to be effective in enhancing energy absorption behavior in the structures while retaining the same relative density. Combining findings from studies on the role of cell geometry, composition, relative density, and fields, this thesis concludes with the development of a design framework that can enable the formulation of cellular material energy absorbers with idealized behavior.
Date Created
2023
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Advanced Manufacturing and Processing of Ceramics and Ceramic Composites

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Description
Achieving a viable process for advanced manufacturing of ceramics and metal-ceramic composites is a sought-after goal in a wide range of fields including electronics and sensors for harsh environments, microelectromechanical devices, energy storage materials, and structural materials, among others. In

Achieving a viable process for advanced manufacturing of ceramics and metal-ceramic composites is a sought-after goal in a wide range of fields including electronics and sensors for harsh environments, microelectromechanical devices, energy storage materials, and structural materials, among others. In this dissertation, the processing, and manufacturing of ceramics and ceramic composites are addressed, specifically, a process for three-dimensional (3D) printing of polymer-derived ceramics (PDC), and a process for low-cost manufacturing as well as healing of metal-ceramic composites is demonstrated.Three-dimensional printing of ceramics is enabled by dispensing the preceramic polymer at the tip of a moving nozzle into a gel that can reversibly switch between fluid and solid states, and subsequently thermally cross-linking the entire printed part “at once” while still inside the same gel was demonstrated. The solid gel converts to fluid at the tip of the moving nozzle, allowing the polymer solution to be dispensed and quickly returns to a solid state to maintain the geometry of the printed polymer both during printing and the subsequent high-temperature (160 °C) cross-linking. After retrieving the cross-linked part from the gel, the green body is converted to ceramic by high-temperature pyrolysis. This scalable process opens new opportunities for low-cost and high-speed production of complex three-dimensional ceramic parts and will be widely used for high-temperature and corrosive environment applications, including electronics and sensors, microelectromechanical systems, energy, and structural applications. Metal-ceramic composites are technologically significant as structural and functional materials and are among the most expensive materials to manufacture and repair. Hence, technologies for self-healing metal-ceramic composites are important. Here, a concept to fabricate and heal co-continuous metal-ceramic composites at room temperature were demonstrated. The composites were fabricated by infiltration of metal (here Copper) into a porous alumina preform (fabricated by freeze-casting) through electroplating; a low-temperature and low-cost process for the fabrication of such composites. Additionally, the same electroplating process was demonstrated for healing damages such as grooves and cracks in the original composite, such that the healed composite recovered its strength by more than 80%. Such technology may be expanded toward fully autonomous self-healing structures.
Date Created
2022
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On the Microstructure, Morphology, and Mechanics of Thin Wall Laser Powder Bed Fusion Structures

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Description
Applications such as heat exchangers, surface-based cellular structures, rotating blades, and waveguides rely on thin metal walls as crucial constituent elements of the structure. The design freedom enabled by laser powder bed fusion has led to an interest in exploiting

Applications such as heat exchangers, surface-based cellular structures, rotating blades, and waveguides rely on thin metal walls as crucial constituent elements of the structure. The design freedom enabled by laser powder bed fusion has led to an interest in exploiting this technology to further the performance of these components, many of which retain their as-built surface morphologies on account of their design complexity. However, there is limited understanding of how and why mechanical properties vary by wall thickness for specimens that are additively manufactured and maintain an as-printed surface finish. Critically, the contributions of microstructure and morphology to the mechanical behavior of thin wall laser powder bed fusion structures have yet to be systematically identified and decoupled. This work focuses on elucidating the room temperature quasi-static tensile and high cycle fatigue properties of as-printed, thin-wall Inconel 718 fabricated using laser powder bed fusion, with the aim of addressing this critical gap in the literature. Wall thicknesses studied range from 0.3 - 2.0 mm, and the effects of Hot Isostatic Pressing are also examined, with sheet metal specimens used as a baseline for comparison. Statistical analyses are conducted to identify the significance of the dependence of properties on wall thickness and Hot Isostatic Pressing, as well as to examine correlations of these properties to section area, porosity, and surface roughness. A thorough microstructural study is complemented with a first-of-its-kind study of surface morphology to decouple their contributions and identify underlying causes for observed changes in mechanical properties. This thesis finds that mechanical properties in the quasi-static and fatigue framework do not see appreciable declines until specimen thickness is under 0.75 mm in thickness. The added Hot Isostatic Pressing heat treatment effectively closed pores, recrystallized the grain structure, and provided a more homogenous microstructure that benefits the modulus, tensile strength, elongation, and fatigue performance at higher stresses. Stress heterogeneities, primarily caused by surface defects, negatively affected the thinner specimens disproportionately. Without the use of the Hot Isostatic Pressing, the grain structure remained much more refined and benefitted the yield strength and fatigue endurance limit.
Date Created
2022
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