Small commercial buildings, or those comprising less than 50,000 square feet of floor area, make up 90% of the total number of buildings in the United States. Though these buildings currently account for less than 50% of total energy consumption in the U.S., this statistic is expected to change as larger commercial buildings become more efficient and thus account for a smaller percentage of commercial building energy consumption. This paper describes the efforts of a multi-organization collaboration and their demonstration partners in developing a library of case studies that promote and facilitate energy efficiency in the small commercial buildings market as well as a case study template that standardized the library. Case studies address five identified barriers to energy efficiency in the small commercial market, specifically lack of: 1) access to centralized, comprehensive, and consistent information about how to achieve energy targets, 2) reasonably achievable energy targets, 3) access to tools that measure buildings’ progress toward targets, 4) financial incentives that make the reduction effort attractive, and 5) effective models of how disparate stakeholders can collaborate in commercial centers to reach targets. The case study library can be organized by location, ownership type, decision criteria, building type, project size, energy savings, end uses impacted, and retrofit measures. This paper discusses the process of developing the library and case study template. Finally, the paper presents next steps in demonstrating the efficacy of the library and explores energy savings potential from broad implementation.

There are many data mining and machine learning techniques to manage large sets of complex energy supply and demand data for building, organization and city. As the amount of data continues to grow, new data analysis methods are needed to address the increasing complexity. Using data from the energy loss between the supply (energy production sources) and demand (buildings and cities consumption), this paper proposes a Semi-Supervised Energy Model (SSEM) to analyse different loss factors for a building cluster. This is done by deep machine learning by training machines to semi-supervise the learning, understanding and manage the process of energy losses. Semi-Supervised Energy Model (SSEM) aims at understanding the demand-supply characteristics of a building cluster and utilizes the confident unlabelled data (loss factors) using deep machine learning techniques. The research findings involves sample data from one of the university campuses and presents the output, which provides an estimate of losses that can be reduced. The paper also provides a list of loss factors that contributes to the total losses and suggests a threshold value for each loss factor, which is determined through real time experiments. The conclusion of this paper provides a proposed energy model that can provide accurate numbers on energy demand, which in turn helps the suppliers to adopt such a model to optimize their supply strategies.

Climatic variables such as temperature have been shown to correlate with demand for mental health services in other countries. An attempt by the present study to replicate this correlation using existing USA treatment data on mental health was not substantiated. Using annual state-level data from 2007 through 2015, the rate of mental health service utilization per 1000 population was correlated with average temperature and precipitation, while adjusting for Gross Domestic Product (GDP), unemployment, and urbanization. No statistically significant correlation was found.

This investigation is focused on the consideration of structural uncertainties in nearly-straight pipes conveying fluid and on the effects of these uncertainties on the dynamic behavior of the pipes. Of interest more specifically are the structural uncertainties which affect directly the fluid flow and its feedback on the structural response, i.e., uncertainties on/variations of the inner cross-section and curvature of the pipe. A finite element-based discovery effort is first carried out on randomly tapered straight pipes to understand how the uncertainty in inner cross-section affects the behavior of the pipes. It is found that the dominant effect originates from the variations of the exit flow speed, induced by the change in inner cross-section at the pipe end, with the uncertainty on the cross-section at other locations playing a secondary role. The development of a generic model of the uncertainty in fluid forces is next considered by proceeding directly at the level of modal models by randomizing simultaneously the appropriate mass, stiffness, and damping matrices. The maximum entropy framework is adopted to carry out the stochastic modeling of these matrices with appropriate symmetry constraints guaranteeing that the nature, e.g., divergence or flutter, of the bifurcation is preserved when introducing uncertainty. To achieve this property, it is proposed that the fluid related mass, damping, and stiffness matrices of the stochastic reduced order model (ROM) all be determined from a single random matrix and a random variable. The predictions from this stochastic ROM are found to closely match the corresponding results obtained with the randomized finite element model.

This paper is part of doctoral research to improve the current Saudi Arabian (SA) procurement system. SA has the largest construction market in the Middle East. However, the use of the traditional procurement system in SA has been identified as one of the causes for poor performance in the delivery of construction. The system has been identified as a major risk to the SA government, due to consistent increased costs and delays of up to 70% on projects. A survey was conducted with 1396 participants including engineers, buyers, contractors, consultants, academics, and architects. The purpose of the survey was to identify the validity of the recent claims that the procurement system in SA is broken. The participants work in both the private and government sectors. The survey results showed that the procurement system is a major risk to projects, affects construction projects negatively, and is in need of improvement.

With the advancement of a growing number of oncolytic viruses (OVs) to clinical development, drug delivery is becoming an important barrier to overcome for optimal therapeutic benefits. Host immunity, tumor microenvironment and abnormal vascularity contribute to inefficient vector delivery. A number of novel approaches for enhanced OV delivery are under evaluation, including use of nanoparticles, immunomodulatory agents and complex viral–particle ligands along with manipulations of the tumor microenvironment. This field of OV delivery has quickly evolved to bioengineering of complex nanoparticles that could be deposited within the tumor using minimal invasive image-guided delivery. Some of the strategies include ultrasound (US)-mediated cavitation-enhanced extravasation, magnetic viral complexes delivery, image-guided infusions with focused US and targeting photodynamic virotherapy. In addition, strategies that modulate tumor microenvironment to decrease extracellular matrix deposition and increase viral propagation are being used to improve tumor penetration by OVs. Some involve modification of the viral genome to enhance their tumoral penetration potential. Here, we highlight the barriers to oncolytic viral delivery, and discuss the challenges to improving it and the perspectives of establishing new modes of active delivery to achieve enhanced oncolytic effects.

Human physical interactions can be intrapersonal, e.g., manipulating an object bimanually, or interpersonal, e.g., transporting an object with another person. In both cases, one or two agents are required to coordinate their limbs to attain the task goal. We investigated the physical coordination of two hands during an object-balancing task performed either bimanually by one agent or jointly by two agents. The task consisted of a series of static (holding) and dynamic (moving) phases, initiated by auditory cues. We found that task performance of dyads was not affected by different pairings of dominant and non-dominant hands. However, the spatial configuration of the two agents (side-by-side vs. face-to-face) appears to play an important role, such that dyads performed better side-by-side than face-to-face. Furthermore, we demonstrated that only individuals with worse solo performance can benefit from interpersonal coordination through physical couplings, whereas the better individuals do not. The present work extends ongoing investigations on human-human physical interactions by providing new insights about factors that influence dyadic performance. Our findings could potentially impact several areas, including robotic-assisted therapies, sensorimotor learning and human performance augmentation.

Biological and robotic grasp and manipulation are undeniably similar at the level of mechanical task performance. However, their underlying fundamental biological vs. engineering mechanisms are, by definition, dramatically different and can even be antithetical. Even our approach to each is diametrically opposite: inductive science for the study of biological systems vs. engineering synthesis for the design and construction of robotic systems. The past 20 years have seen several conceptual advances in both fields and the quest to unify them. Chief among them is the reluctant recognition that their underlying fundamental mechanisms may actually share limited common ground, while exhibiting many fundamental differences. This recognition is particularly liberating because it allows us to resolve and move beyond multiple paradoxes and contradictions that arose from the initial reasonable assumption of a large common ground. Here, we begin by introducing the perspective of neuromechanics, which emphasizes that real-world behavior emerges from the intimate interactions among the physical structure of the system, the mechanical requirements of a task, the feasible neural control actions to produce it, and the ability of the neuromuscular system to adapt through interactions with the environment. This allows us to articulate a succinct overview of a few salient conceptual paradoxes and contradictions regarding under-determined vs. over-determined mechanics, under- vs. over-actuated control, prescribed vs. emergent function, learning vs. implementation vs. adaptation, prescriptive vs. descriptive synergies, and optimal vs. habitual performance. We conclude by presenting open questions and suggesting directions for future research. We hope this frank and open-minded assessment of the state-of-the-art will encourage and guide these communities to continue to interact and make progress in these important areas at the interface of neuromechanics, neuroscience, rehabilitation and robotics.

Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend to be expressed at higher levels in human pluripotent cells than in differentiated cells, raising the possibility that NMD must be downregulated to permit differentiation. Loss- and gain-of-function experiments in human embryonic stem cells (hESCs) demonstrated that, indeed, NMD downregulation is essential for efficient generation of definitive endoderm. RNA-seq analysis identified NMD target transcripts induced when NMD is suppressed in hESCs, including many encoding signaling components. This led us to test the role of TGF-β and BMP signaling, which we found NMD acts through to influence definitive endoderm versus mesoderm fate. Our results suggest that selective RNA decay is critical for specifying the developmental fate of specific human embryonic cell lineages.

There is much reason to believe that fleets of service vehicles of many organizations will transform their vehicles that utilize alternative fuels that are more sustainable. The electric vehicle (EV) is a good candidate for this transformation, especially which “refuels” by exchanging its spent batteries with charged ones. This paper discusses some new logistical issues that must be addressed by such EV fleets, principally the issues related to the limited driving range of each EV's set of charged batteries and the possible detouring for battery exchanges. In particular, the paper addresses (1) the routing and scheduling of the fleet, (2) the locations of battery-exchange stations, and (3) the sizing of each facility. An overview of the literature on the topic is provided and some initial results are presented.