Arizona State University (ASU) is known for both enormous size and scale, as well as excellence in research and innovation. These attributes are embodied in the ideal of the “New American University.” ASU Library, as a partner in the New American University, has reorganized itself, completed a large-scale renovation of its main library building, and created interdisciplinary divisions of librarians and other professionals, backed up by subject “knowledge teams” that address specific research needs of faculty and students. As a result, the library has become involved in nontraditional projects across the university. This article is useful for libraries seeking to remain relevant and align themselves with institutional priorities.