The Italian luxury fashion industry is home to many of the world's top fashion houses and is intricately connected to traditional Italian cultural values. Over the past several decades, Italian luxury fashion has been highly desirable throughout markets across the world due to its exquisite design and craftsmanship. Since the conclusion of World War II the Italian luxury fashion industry has continuously developed and been highly successful in foreign markets, notably including the United States. This study explores cross-cultural management in the Italian luxury fashion industry from an American perspective. The report begins with a brief history of the industry beginning in 1945 and extending into the early 2000s, a period characterized by tremendous growth domestically and abroad. Subsequently, three cross-cultural management frameworks are utilized to compare Italian and American culture values including Erin Meyer's "The Culture Map," Geert Hofstede's Psychological Framework, and Fons Trompenaars' Expansive Framework. This research serves as the foundation for the final component of the report detailing a cross-cultural management framework for American partners in the Italian luxury fashion industry. This framework reflects potential areas of cross-cultural conflict in addition to current trends within the industry, such as increasingly complex supply chains. The framework is divided into four sections \u2014 Strategic Leadership; Internationalization; Value Chains, Sustainability, and Innovation; and Exclusivity and the "Made in Italy" Label in a Global Economy. Along with the discussion of each component, mini case studies highlighting four of the leading companies in the market \u2014 Versace, Gucci, Prada, and Armani \u2014 are included. Each of these mini case studies provides a brief overview of the company and takes a unique perspective illustrating one or more components of the cross-cultural management practices essential to the successful operation of global fashion houses. The report concludes with three cross-cultural dimensions in which American managers should be especially vigilant when navigating the Italian luxury fashion industry including time orientation, task-based versus relationship-based trust, and neutral versus affective communication. The findings from this study are aimed at executive coaching and consulting environments due to the current lack of literature on the Italian luxury fashion industry.