The Sonoran Desert in the Southwest region of the United States and the Northwest corner of Mexico is defined by low precipitation rates that are episodal, oscillating between years of higher yields than average and then below average levels. Water is essential for life and in the region, the lack of water proves an obstacle for people that must be faced to live and thrive there. Yet, millions of people live in this desert region and more people are moving currently. As current water resources are straining not only under increasing population but also with higher frequency and lengths of droughts in the region, water is becoming an important topic for future plans in the Sonoran Desert. However, a vast array of plants and animals have lived under these conditions by adapting to the low precipitation rates. By looking at the common flora and fauna of the region, humans may learn how to better live in the Sonoran Desert through biomimicry, the imitation of life. The natural design and processes of life in the Sonoran Desert can be studied to find ways to conserve, store and collect water for human consumption ensuring longevity within the region and beyond as water insecurity increases globally.