This project develops the "socio-technical contract" concept, a notion that signifies the kinds of socio-technological assumptions and arrangements that characterize a particular domain of policy or practice. Socio-technical contracts, unlike their social contract counterparts in political theory, represent active negotiation and renegotiation of social contracts around emerging technologies, as opposed to the tacit social contracts of thinkers such as Locke. I use the socio-technical contract concept to analyze the governance of assisted reproductive technologies in the United Kingdom. For increasing numbers of people, reproduction is happening in a fundamentally different way. Conception outside of the womb became a reality with the 1978 birth of Louise Brown, the first baby born via in-vitro fertilization. Alongside Louise Brown's birth emerged new social and governance configurations around reproductive technologies, including, in the United Kingdom, the establishment of a national regulatory agency, the Human Fertilisation and Embryology Authority. The project applies the socio-technical contract concept in order to examine how distributed governance and socio-cultural processes in the British context worked over time to renegotiate fundamental ideas about families and kinship, the boundaries of "ethical" science, rules governing release of information, the "right to an identity," the role of the state in the reproductive choices of individuals, and general approaches to how to think about the roles and relationships of the child, parents, and the state in and around the introduction of these technologies. As these changes have occurred, policies, social understandings, and legal rights have been renegotiated and new governance capacities, what I call "anticipatory capacities," have come into existence to manage and coordinate change across complex social systems. In illuminating anticipatory capacities in each context, I explore the tools deployed by government actors, scientists, stakeholders, and citizens in negotiating evolving socio-technical contracts around reproductive technologies.

Cities around the globe struggle with socio-economic disparities, resource inefficiency, environmental contamination, and quality-of-life challenges. Technological innovation, as one prominent approach to problem solving, promises to address these challenges; yet, introducing new technologies, such as nanotechnology, into society and cities has often resulted in negative consequences. Recent research has conceptually linked anticipatory governance and sustainability science: to understand the role of technology in complex problems our societies face; to anticipate negative consequences of technological innovation; and to promote long-term oriented and responsible governance of technologies. This dissertation advances this link conceptually and empirically, focusing on nanotechnology and urban sustainability challenges. The guiding question for this dissertation research is: How can nanotechnology be innovated and governed in responsible ways and with sustainable outcomes? The dissertation: analyzes the nanotechnology innovation process from an actor- and activities-oriented perspective (Chapter 2); assesses this innovation process from a comprehensive perspective on sustainable governance (Chapter 3); constructs a small set of future scenarios to consider future implications of different nanotechnology governance models (Chapter 4); and appraises the amenability of sustainability problems to nanotechnological interventions (Chapter 5). The four studies are based on data collected through literature review, document analysis, participant observation, interviews, workshops, and walking audits, as part of process analysis, scenario construction, and technology assessment. Research was conducted in collaboration with representatives from industry, government agencies, and civic organizations. The empirical parts of the four studies focus on Metropolitan Phoenix. Findings suggest that: predefined mandates and economic goals dominate the nanotechnology innovation process; normative responsibilities identified by risk governance, sustainability-oriented governance, and anticipatory governance are infrequently considered in the nanotechnology innovation process; different governance models will have major impacts on the role and effects of nanotechnology in cities in the future; and nanotechnologies, currently, do not effectively address the root causes of urban sustainability challenges and require complementary solution approaches. This dissertation contributes to the concepts of anticipatory governance and sustainability science on how to constructively guide nanotechnological innovation in order to harvest its positive potential and safeguard against negative consequences.

Gender and sex are often conflated. Our laws, policies, and even science establish sex and gender as intrinsically linked and dimorphic in nature. This dissertation examines the relationship between sex and gender and the repercussions of this linked dimorphism in the realms of law, politics, and science. Chapter One identifies the legal climate for changing one's sexual identity post-surgical reassignment. It pays particular attention to the ability of postsurgical transsexuals to marry in their acquired sex. Chapter Two considers the process for identifying the sex of athletes for the purposes of participation in sex-segregated athletic events, specifically the role of testing and standards for categorization. Chapter Three explores the process of identifying and assigning the sex of intersex children. Chapter Four examines the process of prenatal sex selection and its ethical implications. Chapter Four also offers an anticipatory governance framework to address these implications.

Extant evaluation studies of the Bayh-Dole Act of 1980 have focused primarily on its effects on the pace of innovation and on the norms and practices of academic research but neglected other public values. Seeking to redress this shortcoming, I begin by examining Bayh-Dole with respect to other relevant public values following the Public Value Failure approach. From that analysis, equity emerges as a pressing issue. I define equity issues, in a loosely Rawlsian sense, as situations of unfair distribution of political power and economic resources. My analysis identifies a business model of offices of technology transfer--that I call "nurturing start-ups"--that is likely to become a standard of practice. This model can foster either firm competition or concentration in emerging industries and will therefore have an impact on the distribution of economic benefits from innovation. In addition, political influence to reform Bayh-Dole is allocated disproportionately in favor of those who stand to gain from this policy. For instance, elite universities hold a larger share of the resources and voice of the university system. Consequently, adjusting the nurturing start-ups model to foster competition and increasing cooperation among universities should lead to a more equitable distribution of economic benefits and political voice in technology transfer. Conventional policy evaluation is also responsible for the neglect of equity considerations in Bayh-Dole studies. Currently, "what is the policy impact?" can be answered far more systematically than "why the impact matters?" or "is this policy designed and implemented legitimately?" The problem lies with the consequentialist theory of value that undergirds evaluation. Hence, I propose a deontological theory of evaluation to reaffirm the discipline's commitment to democratic policy making.