Detecting Oligomeric Forms of Alpha-Synuclein in Cell and Mouse Tissue
Description
Misfolding and aggregation of alpha-synuclein (a-syn) has been strongly correlated with the pathogenesis of Parkinson's disease (PD). Reagents such as single chain antibody fragments (scFv) that can interact with specific aggregate forms of a-syn can be very useful to study how different aggregate forms affect cells. Here we utilize two scFvs, D5 and 10H, that recognize two distinct oligomeric forms of a-syn to characterize the presence of different a-syn aggregates in animal models of PD.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-05
Agent
- Author (aut): Alam, Now Bahar
- Thesis director: Sierks, Michael
- Committee member: Pauken, Christine
- Committee member: Williams, Stephanie
- Contributor (ctb): Barrett, The Honors College
- Contributor (ctb): Department of Psychology
- Contributor (ctb): Harrington Bioengineering Program