The Great Plains region of the central United States and southern Canada is a promising location for wind energy resource development. Wind energy site assessments and forecasts can benefit from better understanding the variability that may result from several teleconnections affecting North America. This thesis investigates how the El Niño/Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), and the Pacific/North American Pattern (PNA) impact mean monthly wind speeds at 850 hPa over the Great Plains. Using wind speeds from the NCAR/NCEP Reanalysis 1, correlations were computed between the mean monthly wind speeds and average monthly teleconnection index values. A difference of means test was used to compute the change in wind speeds between the positive and negative phases of each index. ENSO was not found to have a significant impact on wind speeds, while the NAO and PNA patterns weakly affected wind speeds. The NAO index was positively (negatively) correlated with wind speeds over the northern (southern) plains, while the PNA index was negatively correlated with wind speeds over most of the plains. Even a small change in wind speed can have a large effect on the potential power output, so the effects of these teleconnections should be considered in wind resource assessments and climatologies.