Genetically Engineered Salmonella Typhimurium for Targeting & Selective Expression of TRAIL in Necrotizing Tumors
Description
A novel and unconventional approach for delivering a eukaryotic apoptosis factor, TNF-related apoptosis-inducing ligand (TRAIL), to cancer cells within and around necrotizing tumors by utilizing a S. Typhimurium purine requiring auxotroph as a biological vector to develop two anticancer therapies with multiple modality and broad economic feasibility.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-12
Agent
- Author (aut): Koons, Andrew
- Thesis director: Curtiss, Roy
- Committee member: Lake, Douglas
- Committee member: Janthakahalli, Nagaraj Vinay
- Contributor (ctb): Barrett, The Honors College