Cystic fibrosis (CF) is a fatal, inherited disease found in humans and characterized by buildup of thick, sticky mucus, particularly in the respiratory and digestive tracts. The abnormally thick mucus prevents the pancreas from functioning normally; it often leads to digestive problems and chronic lung infections. Cystic fibrosis is most prevalent in Caucasian individuals, and approximately 1 in every 29 individuals in the US is a carrier for the mutated CF gene. There are an estimated 30,000 reported cystic fibrosis cases in the US, and 70,000 reported cases worldwide, although the international number is undoubtedly low due to underreporting or early deaths.

Lap-Chee Tsui is a geneticist who discovered the cystic fibrosis (CF) gene, and his research team sequenced human chromosome 7. As the location of the cystic fibrosis gene is now known, it is possible for doctors and specialists to identify in human fetuses the mutation that causes the fatal disease. Tsui's research also outlined the mechanisms for the development of cystic fibrosis, which were previously unknown.

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene was identified in 1989 by geneticist Lap-Chee Tsui and his research team as the gene associated with cystic fibrosis (CF). Tsui's research pinpointed the gene, some mutations to which cause CF, and it revealed the underlying disease mechanism. The CFTR gene encodes a protein in the cell membrane in epithelial tissues and affects multiple organ systems in the human body. Mutations in the CFTR gene cause dysfunctional regulation of cell electrolytes and water content. Research on the CFTR mutation has shed light on the ways in which this gene is vital to normal human development.

Emergency departments (EDs) across the country have been forced to accommodate an ever-expanding population of mental health patients. This study surveyed physicians and social workers in order to determine the most commonly treated mental illnesses in the ED, common frustrations in the care of mental health patients, limitations in the provision of treatment, and possible changes and improvements to the treatment system for the future. Attitudes toward the deinstitutionalization movement of the 1960s also were assessed, as this movement is hypothesized to have contributed to the current strain on EDs with respect to treating mental health issues. In this thesis, the deinstirutionalization movement and possible implications for mental health treatment in EDs are reviewed' In addition, questionnaires were administered to a sample of 6 ED doctors and 2 ED social workers-. Survey responses suggest that more resources, including availability of ED staff psychiatrists and dedicated facilities for mental health patients' would offer improvements to the current system. With careful evaluation of the ability of the ED to meet the needs of mental health patients, alternative resources for more effective and successful treatment strategies may be developed that offer a compromise between institutionalization and the revolving door of the ED.