Weed, pot, chronic, kaya, and kush are just a few names for one of the world’s most far-reaching and impactful substances. This course is designed with inclusive teaching devices for students to explore how the roots of economies, cultures, and histories have been intertwined with the subsistence of a plant. We will explore the biological and chemical nature of cannabis, historical accounts of human interactions with cannabis, production and industries, medicinal and recreational applications, legal and criminal ramifications, as well as future directions for legislation and economic opportunities. This class is intended to provide you with past research and facts, paired with coverage of events and movements happening today, so that you can make well-informed decisions for your future. The goal of this class is to motivate students to approach the topic of cannabis from various thought perspectives, so they can critically develop both life science knowledge and social science understandings regarding this polarizing subject. At the end of the course, students should be able to 1) Describe the basic anatomy and biology of cannabis plants, and the effects of psychoactive strains of cannabis on humans, 2) Explain the effects of cannabis on U.S. culture, as well as how U.S. culture has shaped the status of cannabis, 3) Differentiate evidence-based arguments from opinions and anecdotal positions, 4) Evaluate the interconnectedness of history, economics, criminal justice, and social contexts as they relate to cannabis, and 5) Demonstrate the ability to integrate evidence-based understandings into creating and disseminating knowledge through structured conversations and organized presentations.