The present study investigated the student population at Arizona State University to: (1) assess how electronic cigarette (e-cigarette) use is associated with subsequent smoking (cigarette, hookah, cigarillo, smokeless tobacco, marijuana) use; (2) investigate the relationship of e-cigarette use with non-electronic smoking cessation, and vice versa; and (3) compare how e-cigarette use is associated with cessation of non-electronic smoking. Based on previous related research and tools, the cross-sectional study included an anonymous online screening, followed by a survey that assessed e-cigarette use and non-electronic smoking, e-cigarette withdrawal and cessation, and non-electronic smoking quit attempts. Participants (N=65) were recruited via flyer advertisements, social media advertisements, ASU online advertisements, and email notices. Major findings of this study include: Participants who used non-electronic smoking primarily used cigarettes or marijuana; participants who used both electronic and non-electronic smoking more frequently used e-cigarettes than non-electronic forms; and participants who previously attempted e-cigarette cession believe that they will successfully withdraw from e-cigarette use in the future, by either using marijuana or not using non-electronic smoking in the future. Based on these findings, nurses should assess all youth and young adults for e-cigarette “core constructs”; provide evidence-based interventions; and encourage future, successful e-cigarette cessation.