Genome-wide mining and comparative analyses of the Toll-like Receptor 7 and 11 gene subfamilies in reptiles
Description
New genomic resources allow for the investigation of gene family diversity in genome-enabled reptiles. The Toll-like Receptor (TLR) gene family recognizes pathogen-associated molecular patterns (PAMPs) and coevolves with environmental pathogens which makes it a strong candidate for looking at the interplay between gene family diversification and host-pathogen coevolution. Using a new orthology curation pipeline and phylogenetic reconstruction, a novel gene expansion event of TLR8 was identified to be exclusive to crocodilians and chelonians with species-specific pseudogenization events. A new gene, TLR21-like, was identified as a part of the TLR11 subfamily. These findings uncover reptile-specific gene family evolution and provide indications of the role of habitat in this process.
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2020-05
Agent
- Author (aut): Morales, Matheo
- Thesis director: Kusumi, Kenro
- Committee member: Dolby, Greer
- Committee member: Scott, Peter
- Contributor (ctb): School of Mathematical and Statistical Sciences
- Contributor (ctb): School of Life Sciences
- Contributor (ctb): Barrett, The Honors College