Characterizing the Porphyromonas Gingivalis PorX-PorY Type IX Secretion System

Description
Porphyromonas Gingivalis (P.G.) is a gram-negative anaerobic bacillus that is commonly implicated in periodontal disease in humans via invasion of oral epithelial cells. Characterizing the intracellular mechanisms that allow for these infections to take place is important for future attempts

Porphyromonas Gingivalis (P.G.) is a gram-negative anaerobic bacillus that is commonly implicated in periodontal disease in humans via invasion of oral epithelial cells. Characterizing the intracellular mechanisms that allow for these infections to take place is important for future attempts to stop or halt the spread of infection. Given the complexity of bacterial virulence, research on the subject often necessitates precise measurements of very specific biochemical pathways. In this study, we focus on the type IX secretion system utilized by P.G. to initiate colonization of host cells. Specific to this secretion system is the PorX-PorY two-component regulatory system. Here we use the bacterial adenylate cyclase based 2 hybrid system to test if two specific domains of the PorX-PorY system communicate intracellularly with each other; and hence gain further knowledge on how this infection occurs.
Date Created
2024-05
Agent

Sharing Patient Praises with Radiology Staff: Workflow Automation and Impact on Staff

Description
Objective: This study aims to develop and evaluate a semi-automated workflow using Natural Language Processing (NLP) for sharing positive patient feedback with radiology staff, assessing its efficiency and impact on radiology staff morale. Methods: The HIPAA compliant, institutional review board-waived implementation

Objective: This study aims to develop and evaluate a semi-automated workflow using Natural Language Processing (NLP) for sharing positive patient feedback with radiology staff, assessing its efficiency and impact on radiology staff morale. Methods: The HIPAA compliant, institutional review board-waived implementation study was conducted from April 2022 to June 2023 and introduced a Patient Praises program to distribute positive patient feedback to radiology staff collected from patient surveys. The study transitioned from an initial manual workflow to a hybrid process using an NLP model trained on 1,034 annotated comments and validated on 260 holdout reports. The time to generate Patient Praises e-mails were compared between manual and hybrid workflows. Impact of Patient Praises on radiology staff was measured using a 4 question Likert-scale survey and an open text feedback box. Kruskal-Wallis and post-hoc Dunn’s test was performed to evaluate differences in time for different workflows. Results: From April 2022 to June 2023, the radiology department received 10,643 patient surveys. Of those surveys, 95.6% of these surveys contained positive comments, with 9.6% (n = 978) shared as Patient Praises to staff. After implementation of the hybrid workflow in March 2023, 45.8% of Patient Praises were sent through the hybrid workflow and 54.2% were sent manually. Time efficiency analysis on 30-case subsets revealed that the hybrid workflow without edits was the most efficient, taking a median of 0.7 minutes per case. A high proportion of staff found the praises made them feel appreciated (94%) and valued (90%) responding with a 5/5 agreement on 5-point Likert scale responses. Conclusion: A hybrid workflow incorporating NLP significantly improves time efficiency for the Patient Praises program while increasing feelings of acknowledgment and value among staff.
Date Created
2024-05
Agent

Examining the Evolution, Effectiveness, and Applicability of the Adverse Childhood Experience Study

Description

Understanding and predicting health outcomes of adults by examining adverse childhood experiences (ACE) is one tool available to healthcare professionals. This tool originated from the 1988 ACE study, and because of its findings, it has been widely implemented and utilized.

Understanding and predicting health outcomes of adults by examining adverse childhood experiences (ACE) is one tool available to healthcare professionals. This tool originated from the 1988 ACE study, and because of its findings, it has been widely implemented and utilized. This literature review investigates how practical and applicable those findings are to validate its current widespread practice. It is concluded that the original study is not comprehensive enough to justify its use in a significant way; however, this review discusses how it can be built upon and modernized to capture more demographics, validate its results to apply to more populations, and become a better predictive model.

Date Created
2023-05
Agent

The Faces of Stigma Behind Plastic Surgery

Description
Plastic surgery has become a target for criticism for quite some time now. By looking into this criticism, the purpose of plastic surgery, its history in medicine, and the ethical concerns associated with it, one can understand why there might

Plastic surgery has become a target for criticism for quite some time now. By looking into this criticism, the purpose of plastic surgery, its history in medicine, and the ethical concerns associated with it, one can understand why there might be debate. The discussed perspectives include negative and positive views, and both will be explored. The effects of the plastic surgery stigma in the form of discrimination and/or societal rewards will be investigated as well. In efforts to understand the stigma, the risks and long-term consequences of plastic surgery will be explored while also looking into the safety of plastic surgery that may invalidate some of the stigma. By comparing plastic surgery to other forms of personal enhancement, the stigma will be challenged by highlighting the juxtaposition of socially acceptable self-improvement methods and non-socially acceptable plastic surgery self-enhancement. Furthermore, this thesis takes a deeper dive into the factors that cause differences between the countries in their views of plastic surgery, and provides a foundational understanding of the root of the stigma while proposing solutions on how to best destigmatize it.
Date Created
2023-05
Agent

Bat Crazy: An Urban Enhancement and Biodiversity Case Study

Description

Due to what is known as the “biologically desert fallacy” and the pervasive westernized ideal of wilderness that has influenced widespread American Conservation culture for millennia, urban areas have long been deemed as areas devoid of biodiversity. However, cities can

Due to what is known as the “biologically desert fallacy” and the pervasive westernized ideal of wilderness that has influenced widespread American Conservation culture for millennia, urban areas have long been deemed as areas devoid of biodiversity. However, cities can contribute significantly to regional biodiversity and provide vital niches for wildlife, illuminating the growing awareness that cities are crucial to the future of conservation and combating the global biodiversity crisis. In terms of the biodiversity crisis, bats are a relevant species of concern. In many studies, different bat species have been broadly classified according to their ability to adapt to urban environments. There is evidence that urban areas can filter bat species based on traits and behavior, with many bats possessing traits that do not allow them to live in cities. The three broad categories are urban avoiders, urban adapters, or urban exploiters based upon where their abundance is highest along a gradient of urban intensity. A common example of an urban exploiter bat is a Mexican Free-tailed bat, which can thrive and rely on urban environments and it is found in the Phoenix Metropolitan area. Bats are important as even in urban environments they play vital ecological roles such as cactus pollination, insect management, and seed dispersal. Bat Crazy is a thesis project focused on urban enhancement and the field of urban biodiversity. The goals of this thesis are to observe how bio-conscious urban cities that work to promote species conservation can serve as a positive tool to promote biodiversity and foster community education and engagement for their urban environment.

Date Created
2023-05
Agent

Why Is There a Social Division of Respect and Perception Between
the Public and Private Sectors of American Law Practitioners?

Description

When it comes to law practitioners in the United States, there is unspoken societal normality to view private practitioners with a certain gold standard. However, in many cases, when public servants are in the limelight, the societal gaze shifts to

When it comes to law practitioners in the United States, there is unspoken societal normality to view private practitioners with a certain gold standard. However, in many cases, when public servants are in the limelight, the societal gaze shifts to this second-hand standard, where many are considered lesser than or “not as good” as their private sector counterparts. When it comes down to it, the practitioners have passed the same/and or similar bar exam (for their respective states) and have gone through the same rigorous education to be where they are today. Both public and private sectors accomplish the same job that is in front of them, but one is paid significantly more, respected higher, and deemed by society the better option. However, clients can not afford the private sector due to privatized rates and are forced to “settle” with the public servant, then by proxy being deemed inadequate and the “loser” in the associated cases prematurely. This notion that there is a stereotype or bias towards public servants needs to be explored to see how pervasive this reality or myth truly is and to explore some of the possible sources for these perceptions.

Date Created
2023-05
Agent

Breaking the Cycle of Oral Health Disparities: Understanding the Global and National Landscape of Health Disparities to Achieve Health Equity Solutions in Oral Health

Description

This thesis addresses the global and national health landscape of disparities to provide insight into the social factors such as education, socioeconomic status, and environment that impact marginalized groups. A positive correlation between race, residency, and lower socioeconomic status among

This thesis addresses the global and national health landscape of disparities to provide insight into the social factors such as education, socioeconomic status, and environment that impact marginalized groups. A positive correlation between race, residency, and lower socioeconomic status among global and national landscapes was made with oral health disparities demonstrating poorer health outcomes among these groups. Through a multistep approach this thesis aimed to provide solutions to contribute to the efforts of developing effective policies and interventions that aim to promote oral health equity.

Date Created
2023-05
Agent

From The Trenches: Experiences of Medical School

Description

Every day people dream of becoming doctors; yet, while many know it is a rigorous process to wear a white coat and practice medicine, the true stories of the trenches of medical school are still often untold. This creative project

Every day people dream of becoming doctors; yet, while many know it is a rigorous process to wear a white coat and practice medicine, the true stories of the trenches of medical school are still often untold. This creative project gives medical students chance to have the spotlight, where they will share their own stories of both the ups and downs of their medical school experience and beyond. They were also given the opportunity to reflect and offer insight on if they would do it all over again or what they would change. This story-gathering of these future medical professionals will provide advice on how to get into medical school and tips on how to become a successful doctor, all while providing real-life stories about the people who save lives, and how it has affected them as an individual.

Date Created
2023-05
Agent

Analysis of Perceived Water Quality in Cusibamba and Totora, Peru

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Description
This study uses a survey-based approach to study the perception of water quality and sanitation habits in Cusibamba and Totora, Peru. The survey covered important aspects such as how the water tastes, looks, smells, where it comes from, how it

This study uses a survey-based approach to study the perception of water quality and sanitation habits in Cusibamba and Totora, Peru. The survey covered important aspects such as how the water tastes, looks, smells, where it comes from, how it is purified (boiled or chlorinated), and if the respondent is satisfied with their water. Participants reported that the water is of good quality overall and usually available (although scarcity may be an issue). They also reported good hygiene practices overall, and that they boil the water prior to using it for cooking, cleaning, or drinking. Educational information about ensuring water quality and sanitation would have been distributed in addition to in-person lessons on how to purify water if the COVID pandemic did not occur. These activities could not have been performed without risk to the communities and risk to those traveling to Peru.
Date Created
2022-05
Agent

The Bioethics of Telemedicine in the United States During COVID-19

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Description

Since the beginning of the COVID-19 pandemic, telemedicine usage in America has experienced extreme peaks as a method of maintaining social distancing for medical staff and patients. While there have been numerous significant positive effects from increasing this practice, there

Since the beginning of the COVID-19 pandemic, telemedicine usage in America has experienced extreme peaks as a method of maintaining social distancing for medical staff and patients. While there have been numerous significant positive effects from increasing this practice, there are also significant risks to be explored. Patients and physicians have been navigating new technology, new protocols, and new dynamics at a high rate. Doctors using telemedicine are required to rely more heavily on their judgment with less data than usual to support their hypotheses. This results in a wide variety of potential complications that can be detrimental to patients and physicians alike. Though negative outcomes are not nearly the majority, it is clear that for telemedicine to function at its fullest capacity, the limitations of its technology must be defined and communicated. A survey was distributed to physicians currently practicing telemedicine to understand more about the usage increase in telemedicine and the incidence rates of telemedicine-related complications. The results showed that although the impact of telemedicine has been largely positive, there certainly are risks that must be considered and prepared for. Thus, it is the responsibility of healthcare systems to ensure that their policies are current and appropriate in proportion to their usage of telemedicine to better protect and prepare patients and doctors for this new frontier of medicine.

Date Created
2022-05
Agent