The Basilisk lizard is known for its agile locomotion capabilities on granular and aquatic media making it an impressive model organism for studying multi-terrain locomotion mechanics. The work presented here is aimed at understanding locomotion characteristics of Basilisk lizards through a systematic series of robotic and animal experiments. In this work, a Basilisk lizard inspired legged robot with bipedal and quadrupedal locomotion capabilities is presented. A series of robot experiments are conducted on dry and wet (saturated) granular media to determine the effects of gait parameters and substrate saturation, on robot velocity and energetics. Gait parameters studied here are stride frequency and stride length. Results of robot experiments are compared with previously obtained animal data. It is observed that for a fixed robot stride frequency, velocity and stride length increase with increasing saturation, confirming the locomotion characteristics of the Basilisk lizard. It is further observed that with increasing saturation level, robot cost of transport decreases. An identical series of robot experiments are performed with quadrupedal gait to determine effects of gait parameters on robot performance. Generally, energetics of bipedal running is observed to be higher than quadrupedal operation. Experimental results also reveal how gait parameters can be varied to achieve different desired velocities depending on the substrate saturation level. In addition to robot experiments on granular media, a series of animal experiments are conducted to determine and characterize strategies

exhibited by Basilisk lizards when transitioning from granular to aquatic media.

Wearable robotics has gained huge popularity in recent years due to its wide applications in rehabilitation, military, and industrial fields. The weakness of the skeletal muscles in the aging population and neurological injuries such as stroke and spinal cord injuries seriously limit the abilities of these individuals to perform daily activities. Therefore, there is an increasing attention in the development of wearable robots to assist the elderly and patients with disabilities for motion assistance and rehabilitation. In military and industrial sectors, wearable robots can increase the productivity of workers and soldiers. It is important for the wearable robots to maintain smooth interaction with the user while evolving in complex environments with minimum effort from the user. Therefore, the recognition of the user's activities such as walking or jogging in real time becomes essential to provide appropriate assistance based on the activity.

This dissertation proposes two real-time human activity recognition algorithms intelligent fuzzy inference (IFI) algorithm and Amplitude omega ($A \omega$) algorithm to identify the human activities, i.e., stationary and locomotion activities. The IFI algorithm uses knee angle and ground contact forces (GCFs) measurements from four inertial measurement units (IMUs) and a pair of smart shoes. Whereas, the $A \omega$ algorithm is based on thigh angle measurements from a single IMU.

This dissertation also attempts to address the problem of online tuning of virtual impedance for an assistive robot based on real-time gait and activity measurement data to personalize the assistance for different users. An automatic impedance tuning (AIT) approach is presented for a knee assistive device (KAD) in which the IFI algorithm is used for real-time activity measurements. This dissertation also proposes an adaptive oscillator method known as amplitude omega adaptive oscillator ($A\omega AO$) method for HeSA (hip exoskeleton for superior augmentation) to provide bilateral hip assistance during human locomotion activities. The $A \omega$ algorithm is integrated into the adaptive oscillator method to make the approach robust for different locomotion activities. Experiments are performed on healthy subjects to validate the efficacy of the human activities recognition algorithms and control strategies proposed in this dissertation. Both the activity recognition algorithms exhibited higher classification accuracy with less update time. The results of AIT demonstrated that the KAD assistive torque was smoother and EMG signal of Vastus Medialis is reduced, compared to constant impedance and finite state machine approaches. The $A\omega AO$ method showed real-time learning of the locomotion activities signals for three healthy subjects while wearing HeSA. To understand the influence of the assistive devices on the inherent dynamic gait stability of the human, stability analysis is performed. For this, the stability metrics derived from dynamical systems theory are used to evaluate unilateral knee assistance applied to the healthy participants.

The world population is aging. Age-related disorders such as stroke and spinal cord injury are increasing rapidly, and such patients often suffer from mobility impairment. Wearable robotic exoskeletons are developed that serve as rehabilitation devices for these patients. In this thesis, a knee exoskeleton design with higher torque output compared to the first version, is designed and fabricated.

A series elastic actuator is one of the many actuation mechanisms employed in exoskeletons. In this mechanism a torsion spring is used between the actuator and human joint. It serves as torque sensor and energy buffer, making it compact and

safe.

A version of knee exoskeleton was developed using the SEA mechanism. It uses worm gear and spur gear combination to amplify the assistive torque generated from the DC motor. It weighs 1.57 kg and provides a maximum assistive torque of 11.26 N·m. It can be used as a rehabilitation device for patients affected with knee joint impairment.

A new version of exoskeleton design is proposed as an improvement over the first version. It consists of components such as brushless DC motor and planetary gear that are selected to meet the design requirements and biomechanical considerations. All the other components such as bevel gear and torsion spring are selected to be compatible with the exoskeleton. The frame of the exoskeleton is modeled in SolidWorks to be modular and easy to assemble. It is fabricated using sheet metal aluminum. It is designed to provide a maximum assistive torque of 23 N·m, two times over the present exoskeleton. A simple brace is 3D printed, making it easy to wear and use. It weighs 2.4 kg.

The exoskeleton is equipped with encoders that are used to measure spring deflection and motor angle. They act as sensors for precise control of the exoskeleton.

An impedance-based control is implemented using NI MyRIO, a FPGA based controller. The motor is controlled using a motor driver and powered using an external battery source. The bench tests and walking tests are presented. The new version of exoskeleton is compared with first version and state of the art devices.

Lower-limb wearable assistive robots could alter the users gait kinematics by inputting external power, which can be interpreted as mechanical perturbation to subject normal gait. The change in kinematics may affect the dynamic stability. This work attempts to understand the effects of different physical assistance from these robots on the gait dynamic stability.

A knee exoskeleton and ankle assistive device (Robotic Shoe) are developed and used to provide walking assistance. The knee exoskeleton provides personalized knee joint assistive torque during the stance phase. The robotic shoe is a light-weighted mechanism that can store the potential energy at heel strike and release it by using an active locking mechanism at the terminal stance phase to provide push-up ankle torque and assist the toe-off. Lower-limb Kinematic time series data are collected for subjects wearing these devices in the passive and active mode. The changes of kinematics with and without these devices on lower-limb motion are first studied. Orbital stability, as one of the commonly used measure to quantify gait stability through calculating Floquet Multipliers (FM), is employed to asses the effects of these wearable devices on gait stability. It is shown that wearing the passive knee exoskeleton causes less orbitally stable gait for users, while the knee joint active assistance improves the orbital stability compared to passive mode. The robotic shoe only affects the targeted joint (right ankle) kinematics, and wearing the passive mechanism significantly increases the ankle joint FM values, which indicates less walking orbital stability. More analysis is done on a mechanically perturbed walking public data set, to show that orbital stability can quantify the effects of external mechanical perturbation on gait dynamic stability. This method can further be used as a control design tool to ensure gait stability for users of lower-limb assistive devices.

Soft Poly-Limb (SPL) is a pneumatically driven, wearable, soft continuum robotic arm designed to aid humans with medical conditions, such as cerebral palsy, paraplegia, cervical spondylotic myelopathy, perform activities of daily living. To support user's tasks, the SPL acts as an additional limb extending from the human body which can be controlled to perform safe and compliant mobile manipulation in three-dimensional space. The SPL is inspired by invertebrate limbs, such as the elephant trunk and the arms of the octopus. In this work, various geometrical and physical parameters of the SPL are identified, and behavior of the actuators that comprise it are studied by varying their parameters through novel quasi-static computational models. As a result, this study provides a set of engineering design rules to create soft actuators for continuum soft robotic arms by understanding how varying parameters affect the actuator's motion as a function of the input pressure. A prototype of the SPL is fabricated to analyze the accuracy of these computational models by performing linear expansion, bending and arbitrary pose tests. Furthermore, combinations of the parameters based on the application of the SPL are determined to affect the weight, payload capacity, and stiffness of the arm. Experimental results demonstrate the accuracy of the proposed computational models and help in understanding the behavior of soft compliant actuators. Finally, based on the set functional requirements for the assistance of impaired users, results show the effectiveness of the SPL in performing tasks for activities of daily living.

Human locomotion is an essential function that enables individuals to lead healthy, independent lives. One important feature of natural walking is the capacity to transition across varying surfaces, enabling an individual to traverse complex terrains while maintaining balance. There has been extensive work regarding improving prostheses' performance in changing walking conditions, but there is still a need to address the transition from rigid to compliant or dynamic surfaces, such as the transition from pavement to long grass or soft sand. This research aims to investigate the mechanisms involved such transitions and identify potential indicators of the anticipated change that can be applied to the control of a powered ankle prosthetic to reduce falls and improve stability in lower-limb amputees in a wider range of walking environments. A series of human subject experiments were conducted using the Variable Stiffness Treadmill (VST) to control walking surface compliance while gait kinematics and muscular activation data were collected from three healthy, nondisabled subjects. Specifically, the kinematics and electromyography (EMG) profiles of the gait cycles immediately preceding and following an expected change in surface compliance were compared to that of normal, rigid surface walking. While the results do not indicate statistical differences in the EMG profiles between the two modes of walking, the muscle activation appears to be qualitatively different from inspection of the data. Additionally, there were promising statistically significant changes in joint angles, especially in observed increases in hip flexion during the swing phases both before and during an expected change in surface. Decreases in ankle flexion immediately before heel strike on the perturbed leg were also observed to occur simultaneously with decreases in tibialis anterior (TA) muscle activation, which encourages additional research investigating potential changes in EMG profiles. Ultimately, more work should be done to make strong conclusions about potential indicators of walking surface transitions, but this research demonstrates the potential of EMG and kinematic data to be used in the control of a powered ankle prosthetic.

The interaction between humans and robots has become an important area of research as the diversity of robotic applications has grown. The cooperation of a human and robot to achieve a goal is an important area within the physical human-robot interaction (pHRI) field. The expansion of this field is toward moving robotics into applications in unstructured environments. When humans cooperate with each other, often there are leader and follower roles. These roles may change during the task. This creates a need for the robotic system to be able to exchange roles with the human during a cooperative task. The unstructured nature of the new applications in the field creates a need for robotic systems to be able to interact in six degrees of freedom (DOF). Moreover, in these unstructured environments, the robotic system will have incomplete information. This means that it will sometimes perform an incorrect action and control methods need to be able to correct for this. However, the most compelling applications for robotics are where they have capabilities that the human does not, which also creates the need for robotic systems to be able to correct human action when it detects an error. Activity in the brain precedes human action. Utilizing this activity in the brain can classify the type of interaction desired by the human. For this dissertation, the cooperation between humans and robots is improved in two main areas. First, the ability for electroencephalogram (EEG) to determine the desired cooperation role with a human is demonstrated with a correct classification rate of 65%. Second, a robotic controller is developed to allow the human and robot to cooperate in six DOF with asymmetric role exchange. This system allowed human-robot cooperation to perform a cooperative task at 100% correct rate. High, medium, and low levels of robotic automation are shown to affect performance, with the human making the greatest numbers of errors when the robotic system has a medium level of automation.

Fall accident is a significant problem associated with our society both in terms of economic losses and human suffering [1]. In 2016, more than 800,000 people were hospitalized and over 33,000 deaths resulted from falling. Health costs associated with falling in 2016 yielded at 33% of total medical expenses in the US- mounting to approximately $31 billion per year. As such, it is imperative to find intervention strategies to mitigate deaths and injuries associated with fall accidents. In order for this goal to be realized, it is necessary to understand the mechanisms associated with fall accidents and more specifically, the movement profiles that may represent the cogent behavior of the locomotor system that may be amendable to rehabilitation and intervention strategies. In this light, this Thesis is focused on better understanding the factors influencing dynamic stability measure (as measured by Lyapunov exponents) during over-ground ambulation utilizing wireless Inertial Measurement Unit (IMU).

Four pilot studies were conducted: the First study was carried out to verify if IMU system was sophisticated enough to determine different load-carrying conditions. Second, to test the effects of walking inclinations, three incline levels on gait dynamic stability were examined. Third, tested whether different sections from the total gait cycle can be stitched together to assess LDS using the laboratory collected data. Finally, the fourth study examines the effect of “stitching” the data on dynamic stability measure from a longitudinally assessed (3-day continuous data collection) data to assess the effects of free-range data on assessment of dynamic stability.

Results indicated that load carrying significantly influenced dynamic stability measure but not for the floor inclination levels – indicating that future use of such measure should further implicate normalization of dynamic stability measures associated with different activities and terrain conditions. Additionally, stitching method was successful in obtaining dynamic stability measure utilizing free-living IMU data.

This study presents quantification of ankle stability as affected by environmental conditions in two degrees of freedom (DOF) with three distinct analysis techniques. Additionally, this study presents gender-specific trends for comparison. Intuitively, ankle stability decreased in less stable environments with a negative simulated stiffness. Female subjects generally suffered a greater loss of stability in moderately and highly unstable environments. Both gender groups exhibited greater stability in the sagittal plane than the frontal plane across the entire range of simulated stiffness's. Outcomes of this study are useful in the design of controllers for lower extremity physically-interactive robotics, understanding situations in which the ankle is likely to lose stability, and understanding the strengths and weaknesses of unique analysis techniques.

The quality of life of many people is lowered by impediments to walking ability caused by neurological conditions such as strokes. Since the ankle joint plays an important role in locomotion, it is a common subject of study in rehabilitation research. Robotic devices such as active ankle-foot orthoses and powered exoskeletons have the potential to be used directly in physical therapy or indirectly in research pursuing more effective rehabilitation methods. This paper presents the LiTREAD, a lightweight three degree-of-freedom robotic exoskeletal ankle device. This novel robotic system is designed to be worn on a user's leg and actuate the foot position during treadmill studies. The robot's sagittal plane actuation is complemented by passive virtual axis systems in the frontal and transverse planes. Together, these degrees of freedom allow the device to approximate the full range of motion of the ankle. The virtual axis mechanisms feature locking configurations that will allow the effect of these degrees of freedom on gait dynamics to be studied. Based on a kinematic analysis of the robot's actuation and geometry, it is expected to meet and exceed its torque and speed targets, respectively. The device will fit either leg of a range of subject sizes, and is expected to weigh just 1.3 kg (2.9 lb.). These features and characteristics are designed to minimize the robot's interference with the natural walking motion. Pending validation studies confirming that all design criteria have been met, the LiTREAD prototype that has been constructed will be utilized in various experiments investigating properties of the ankle such as its mechanical impedance. It is hoped that the LiTREAD will yield valuable data that will expand our knowledge of the ankle and aid in the design of future lower-extremity devices.