Approximately 15,000 children die every day due to preventable illnesses (World Health Organization, 2016, 2017). Most of these deaths have been concentrated in developing countries and specifically in Sub-Saharan Africa, South Asia and to a lesser extent in Central Asia. Many studies have analyzed determinants of infant mortality rates across regions of South Asia. Despite neighboring South Asia, reasons for infant mortality in Central Asia do not seem to be as heavily researched. To investigate whether there are differences in the risk factors for infant mortality between South Asia and Central Asia, I analyzed data on 557,089 women and 1,272,916 children from Demographic Health Surveys and Multiple Indicator Cluster Surveys in 5 Central Asian (Azerbaijan, Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan) and 5 South Asian (Afghanistan, Bangladesh, India, Nepal, Pakistan) countries. Binary logistic regression predicted whether a child was alive based on a number of maternal and child characteristics, including maternal age, maternal education, maternal residence, place of delivery, wealth, open defecation, prenatal care, and vaccinations. There were similarities along with differences in child survival outcomes between Central Asia and South Asia. Maternal age, maternal education, and the DPT 3 vaccination appeared to have protective effects on child survival rates in both Central Asia and South Asia whereas delivery outside of the hospital and open defecation have negative effects on child survival outcomes. Tetanus, polio 1, and the BCG vaccinations appeared to have a more pronounced positive effect on child survival in Central Asia whereas measles and polio 3 appear to have a more pronounced positive effect in South Asia. Wealth also appeared to have a greater protective effect in South Asia as opposed to Central Asia. More research needs to be conducted to elaborate on reasons for why there are differences between Central Asia and South Asia.