Circadian misalignments in terms of eat and sleep cycles, common occurrences among college students, are linked to adverse health outcomes. Time-restricted feeding, a form of intermittent fasting, may offer an exciting, non-pharmacologic approach to improve the health of this population by restricting eating to feeding windows that align with circadian biology. This study aims to fill a gap in the literature regarding the effect of early time-restricted feeding (eTRF) on college students, particularly in regard to diet quality, diet self-efficacy, and sleep quality. To test the hypothesis that eTRF would lead to an increase in all three variables, a 4-wk randomized-controlled, parallel arm trial was conducted. Thirty-five healthy college students were randomly assigned to one of two groups: the intervention group (TRF) was instructed to adhere to an 8-h feeding window aligned with the light cycle (9 am to 5 pm), and the control group (CON) was instructed to adhere to a 12-h feeding window typical of college students (10 am to 10pm). The eTRF diet was consumed ad libitum, and the participants were not instructed to avoid compensatory hyperphagia. The results showed a strong, reverse effect of eTRF on diet quality: fasting had a highly significant association with decreased diet quality. The results suggest that, under free-living conditions, college students practicing eTRF are more likely to compensate for prolonged fasting with unhealthy eating and snacking.

In the United States, two-thirds of adults are considered hypertensive orprehypertensive. In addition, chronic illness, such as hypertension, cardiovascular disease, and type II diabetes, results in $3.5 trillion in annual healthcare cost and is the primary cause of disability and death. As a result, many individuals seek cheaper and simpler alternatives to combat their conditions. In this exploratory analysis, a study assessing nitrate intake and its effects on vascular function in 39 young adult males was investigated for underlying metabolic variations through a liquid chromatography – mass spectrometry-based large-scale targeted metabolomics approach. A two-way repeated measures ANOVA was used, and 18 significant metabolites were discovered across the time, treatment, and time & treatment groups, including prostaglandin E2 (p<0.001), stearic acid (p=0.002), caprylic acid (p=0.016), pentadecanoic acid (p=0.027), and heptadecanoic acid (p=0.005). In addition, log-transformed principal component analysis and orthogonal partial least squares – discriminant analysis models demonstrated distinct separation among the treatment, control, and time variables. Moreover, pathway and enrichment analyses validated the effect of nitrate intake on the metabolite sets and its possible function in fatty acid oxidation. This better understanding of altered metabolic pathways may help explicate the benefits of nitrate on vascular function and reveal any unknown mechanisms of its supplementation.

This study was designed to examine the associations between food skills, resilience, and coping during the Covid-19 pandemic. Between April and June of 2020, a sample of 154 students, faculty, and staff from Arizona State University were surveyed. Each respondent was administered a survey containing demographic questions, a food skill questionnaire, and the 14-item Resilience Scale (RS). Results indicate that food skill was correlated with resilience (p<0.001) at an r=0.364 and r2=0.1243 and that resilience was correlated with coping during the Covid-19 pandemic (p<0.001) at an r=0.455. Correlations were also run between resilience score and the separate domains of food skill score: all domains remained significantly associated with resilience score (p<0.001) with a r=0.340 and r2=0.1173 for ‘Food Selection and Planning,’ r=0.312 and r2=0.0958 for ‘Food Preparation,’ and r=0.294 and r2=0.0767 for ‘Food Safety.’ Data seems to be consistent with contemporary research suggesting positive associations between diet quality and physiological resilience and positive associations between resilience and coping during the Covid-19 pandemic.

The assessment and evaluation of dietary intake and nutrition knowledge in female athletes is especially important due to the high prevalence of inadequate intake in this population (Black et al., 2019). This study evaluated 1) the relationship of nutrition knowledge and dietary intake among collegiate female athletes at the National Collegiate Athletic Association (NCAA) Division I, National Junior College Athletic Association (NJCAA), and Club sport levels and 2) the impact of competition level on this relationship as well. Participants (NCAA DI, n=51; NJCAA, n = 36; Club, n = 37) in this study answered two questionnaires, the Nutrition Sport Knowledge Questionnaire (NSKQ) and the Rapid Eating Assessment for Participants (REAP) questionnaire to assess knowledge and dietary intake. Participants also provided anthropometric and demographic information. The NSKQ was scored as a whole and for each of the four subcategories. REAP was scored both by tallying the number of “usually/often” frequency responses and given a numeral score to estimate diet quality. Statistical analysis was conducted using Kruskal-Wallis, Chi-square and Spearman’s correlation tests to compare differences within subgroups of participants and evaluate any relationships that may exist between nutrition knowledge and dietary intake with significance set at p≤0.05. Differences in nutrition knowledge between competition groups were significant, H(2)= 16.94, p< 0.001. NCAA DI (p<0.001) and Club (p<0.001) athletes had higher nutrition knowledge than athletes at the NJCAA level. This was true for overall knowledge as well as knowledge subcategories. However, minimal relationships between nutrition knowledge and dietary intake were found. The overall correlation value was rs(118)= -0.10 (95%CI: -0.28 to 0.08), p>0.05. This suggests those with higher nutrition knowledge did not necessarily have better dietary intake. Improvements in the assessment of nutrition knowledge and quick assessment of dietary quality and the relation between both is needed.

ABSTRACT

Background. College students’ modifiable health behaviors, including unhealthful eating patterns, predispose them to risk for future cardiometabolic conditions.

Purpose. This novel 8-week randomized control parallel-arm study compared the effects of a daily 18-hour Time-Restricted Feeding protocol vs. an 8-hour fast on diet quality in college students. Secondary outcomes were resting morning blood pressure, biomarkers of glucose regulation, biomarkers of lipid metabolism, and anthropometric measures.

Methods. Eighteen healthy college students (age = 23 ± 4 years; BMI = 23.2 ± 2.3 kg/m2; MET = 58.8 ± 32.9 min/wk) completed this study. Participants were randomized to a daily 18-hour fasting protocol (Intervention; n = 8) or a daily 8-hour fasting protocol (Control; n = 10) for eight weeks. One ‘cheat’ day was permitted each week. Outcomes were measured at weeks 0 (baseline), 4, and 8. A non-parametric Mann Whitney U test was used to compare the week 4 change from baseline between groups. Statistical significance was set at p≤0.05.

Results. Diet quality (p = 0.030) and body weight (p = 0.016) improved from baseline to week 4 for the INV group in comparison to the CON group. The data suggest these improvements may be related to reductions in snacking frequency and increased breakfast consumption. Fasting blood glucose and hip circumference tended to improve for the INV group in comparison to the CON group (p = 0.091 and p = 0.100). However, saturated fat intake tended to increase in the INV group in comparison to the CON group (p = 0.064). Finally, there were no treatment differences between groups (p>0.05) for the 4-week change in total calories, dietary vitamin C, added sugars, resting systolic blood pressure, resting diastolic blood pressure, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), low-density lipoprotein (LDL) cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, waist circumference, or MET.

Conclusion. These data, although preliminary, suggest that the 18-hour fasting protocol was effective for improving diet quality and reducing weight in comparison to the 8-hour fasting protocol in healthy college students. Future intervention trials will need to confirm these findings and determine the long-term relevance of these improvements for health outcomes.

Introduction: A diet high in fermented, oligio-, di-, monosaccharide, and polyols

(FODMAP) has been shown to exacerbate symptoms of irritable bowel syndrome

(IBS). Previous literature has shown significant improvement in IBS symptoms after

adherence to a low FODMAP diet (LFD). However, dietary adherence to the LFD is

difficult with patients stating that information provided by healthcare providers

(HCPs) is generalized and nonspecific requiring them to search for supplementary

information to fit their needs. Notably, studies that have used a combination of

online and in-person methods for treatment have shown improved adherence to the

LFD. Objective: To determine whether a novel artificial intelligence (AI) dietary

mobile application will improve adherence to the LFD compared to a standard online

dietary intervention (CON) in populations with IBS or IBS-like symptoms over a 4-

week period. Methods: Participants were randomized into two groups: APP or CON.

The intervention group was provided access to an AI mobile application, a dietary

resource verified by registered dietitians which uses artificial intelligence to

individualize dietary guidance in real-time with the ability to scan menus and

barcodes and provide individuals with food scores based on their dietary preferences.

Primary measures included mobile app engagement, dietary adherence, and

manifestation of IBS-like symptoms. Baseline Results: A total of 58 participants

were randomized to groups. This is an ongoing study and this thesis details the

methodology and baseline characteristics of the participants at baseline and

intervention start. Validation of the application could improve the range of offerings

for lifestyle diseases treatable through dietary modification.

Ketone bodies are produced in the liver from the acetyl CoA derived from fatty acids that cannot enter the Krebs cycle. This is a sub-analysis of a larger study which had numerous outcome markers. This analysis focuses on the relationship between ketone blood levels and cognition. The study looked at the relationship between Time Restricted Feeding (TRF), a method of intermittent fasting. TRF is something that can be easily adapted into an individual’s lifestyle and has been shown to have multiple advantages. This 8-week study began with 23 enrolled participants, but due to COVID-19 only 11 participants could be tested for cognition and blood ketone levels after week 4. All participants had similar ranges of weight, height, age, BMI, hip, and waist measurements at baseline. Moreover, these demographic variables were not related to ketone levels or cognition. The data indicate that ketone bodies increased in participants practicing TRF and that the increase in ketone bodies in the blood, specifically β-hydroxybutyrate was strongly correlated to increased cognitive function. This is consistent with theories that elevated ketone levels allowed for early hunter-gather communities and other mammals to survive prolonged periods of nutrient deprivation while keeping high cognitive function.

Osteosarcopenia is a newly formed term that combines the symptoms of osteoporosis and sarcopenia together because of their concurrent appearances in life. They are both age-related, debilitating conditions that affect older adults’ skeleton and musculoskeletal system. Osteoporosis specifically targets the cells of the bone and make them weak and porous. Sarcopenia attacks the skeletal muscles and deteriorates the muscle fibers, decreasing mass and strength. Both diseases put sedentary elders at high risk of sustaining fractures and proneness to fall. The manifestation of one condition typically leads to the other because of their obvious physical attachments as well as their direct chemical crosstalk. The onset of osteosarcopenia is subtle coinciding with age related processes that become greatly exacerbated and accelerated when coupled with chronic inactivity. Thus, a critical intervention for managing the disability associated with osteosarcopenia is physical activity. While some pharmacological treatments or supplements are known to have positive results in stemming further bone loss, regular participation in moderate-intensity exercises is considered the most effective treatment for attenuating further bone and muscle loss.

Those that must follow a Celiac diet should know that there are challenges that come with it. Wheat contains a ton of essential vitamins and minerals such as folate, magnesium, thiamin and niacin among many others. By cutting these out, it is possible to become deficient in these essential nutrients that play roles all throughout the body. One of our goals in making this cookbook was to include recipes that would be packed with these dietary components. We wanted to not only make this cookbook tangible for newly-diagnosed Celiac people, but also ensure that they have the balanced diet they need to avoid deficiencies. While admittedly not every meal is going to be loaded with those good vitamins and minerals, we believe the phrase “everything in moderation” is a good way to approach this new diet.

Birds maintain resting plasma glucose concentrations (pGlu) nearly twice that of comparably sized mammals. Despite this, birds do not incur much of the oxidative tissue damage that might be expected from a high pGlu. Their ability to stave off oxidative damage allows birds to serve as a negative model of hyperglycemia-related complications, making them ideal for the development of new diabetes treatments with the potential for human application. Previous studies conducted by the Sweazea Lab at Arizona State University aimed to use diet as a means to raise blood glucose in mourning doves (Zenaida macroura) in order to better understand the mechanisms they utilize to stave off oxidative damage. These protocols used dietary interventions—a 60% high fat (HF) “chow” diet, and a high carbohydrate (HC) white bread diet—but were unsuccessful in inducing pathologies. Based on this research, we hypothesized that a model of an urban diet (high in fat, refined carbohydrates, and sodium) might impair vasodilation, as the effect of this diet on birds is currently unknown. We found that tibial vasodilation was significantly impaired in birds fed an urban diet compared to those fed a seed diet. Unexpectedly, vasodilation in the urban diet group was comparable to data of wild-caught birds from previous research, possibly indicating that the birds had already been eating a diet similar to this study’s urban diet before they were caught. This may constitute evidence that the seed diet improved vasodilation while the urban diet more closely mimicked the diet of the birds before the trial, suggesting that the model of the urban diet acted as the control diet in this context. This study is the first step in elucidating avian mechanisms for dealing with diabetogenic diets and has potential to aid in the development of treatments for humans with metabolic syndrome.