This research examines supply chain performance and antecedents to better supply chain performance in manufacturing organizations, with a focus on manufacturing organizations following engineer-to-order and assemble-to-order production models. The variables of supply chain integration, internal communication, employee satisfaction, leader support, and the alignment of information and communication technology are empirically supported in affecting supply chain performance, and thus carry managerial and organizational implications in how they can be influenced, ideally for the benefit of manufacturing organizations. The data gathered for this study was obtained through interviews with sourcing professionals, as well as surveys distributed to corporate manufacturing employees. The findings on these variables fall in line with previous research explored in the report, adding credibility to previous studies, as well as their associated recommendations and implications. Organizational management and leadership, to improve supply chain performance, must strategically integrate information and communication technology, be clear and consistent in their messaging to employees, engage in effective conflict resolution, and provide support for necessary transparency and communication-enhancing initiatives.