Marine plastic pollution (MPP) has emerged as one of the most pressing global environmental challenges of the anthropocene. There has been an upsurge in investment to mitigate MPP; however, interventions can be costly, inequitable, and ineffective in achieving their objectives. In my dissertation, I aim to research key considerations for creating cost-effective, equitable mitigation strategies for MPP and its impacts to marine biodiversity and coastal communities. In chapter one, I introduce the challenges plastic pollution poses. In chapter two, I use seascape ecology theory to present the concept of the plastic-scape and describe how seascape ecology principles, methods, and approaches to transdisciplinary science can inform research to mitigate MPP. In chapter three, I present a framework to help decision makers estimate the total cost of MPP interventions and partial costs accrued by stakeholder groups. I then apply this framework to two quantitative case studies and four comparative case studies to exemplify its use and highlight the ways spatial scale, temporal scale, and socio-economic conditions influence the intervention cost and cost distribution. In chapter four, I employ a trait-based approach to produce a framework for developing indices of species vulnerability to macroplastic pollution. Finally, in chapter five, I implement the framework developed in the previous chapter and present a multi-taxonomic, macroplastic vulnerability index for three marine taxa—mammals, birds, and turtles—to identify the marine species most vulnerable to macroplastic pollution in Hawai‘i. Overall, my dissertation shows how policy-driven, systemic research of MPP and its interventions can improve efforts to address MPP and its socio-economic and ecological consequences.