This study compares vaccine hesitancy during the COVID-19 pandemic with previous studies on vaccine hesitancy to evaluate the major driving factors behind COVID-19 vaccine hesitancy among undergraduate students at Arizona State University (ASU). Undergraduate students were surveyed with questions regarding different aspects of vaccines, including personal vaccination history, opinions on the COVID-19 vaccine, knowledge of the COVID-19 vaccine, and reasoning behind vaccination status. The survey was distributed through school listservs within ASU. Close-ended questions underwent statistical analysis on IBM SPSS and open-ended questions were analyzed using content analysis. Results indicated that the main driving factors behind vaccine hesitancy are believing in natural immunity, familial influence, lack of trust behind the technology of the COVID-19 vaccine, and preferring the risk of COVID-19 infection over the risk of COVID-19 vaccination. The main driving factors behind vaccine hesitancy appear to be similar to driving factors in the past, with an increase of mistrust surrounding the vaccine.