The Balloon-borne Large Aperture Submillimeter Telescope - The Next Generation (BLAST-TNG) was designed to map the polarized emission from dust in star forming regions of our galaxy. The dust is thought to trace magnetic fields and thus inform us of the role that it plays in star formation. BLAST-TNG improves upon the previous generation of balloon-borne sub-mm polarimeters by increasing the number of detectors by over an order of magnitude. A novel detector technology which is naturally multiplexed, Kinetic Inductance Detectors have been developed as an elegant solution to the challenge of packing cryogenic focal plane arrays with detectors. To readout the multiplexed arrays, custom firmware and control software was developed for the ROACH2 FPGA based system. On January 6th 2020 the telescope was launched on a high-altitude balloon from Antarctica and flew for approximately 15 hours in the mid-stratosphere. During this time various calibration tasks occurred such as atmospheric skydips, the mapping of a sub-mm source, and the flashing of an internal calibration lamp. A mechanical failure shortened the flight so that only calibration scans were performed. In this dissertation I will present my analysis of the in-flight calibration data leading to measures of the overall telescope sensitivity and detector performance. The results of which prove kinetic inductance detectors as a viable candidate for future space based sub-mm telescopes. In parallel the fields of digital communications and radar signal processing have spawned the development of the Radio Frequency System On a Chip (RFSoC). This product by Xilinx incorporates a fabric of reconfigurable logic, ARM microprocessors, and high speed digitizers all into one chip. The system specs provide an improvement in every category of size, weight, power, and bandwidth.This is naturally the desired platform for the next generation of far-infrared telescopes which are pushing the limits of detector counts. I present the development of one of the first frequency multiplexed detector readouts on the RFSoC platform. Alternative firmware designs implemented on the RFSoC are also discussed. The firmware work presented will be used in part or in full for multiple current and upcoming far-infrared telescopes.