The present study examines the role of uncertainty and how it relates to variables pertinent to student success such as anxiety, future self-identification, and academic self-efficacy. The present study consists of two parts. Part 1 of the study aims to address whether levels of perceived uncertainty predict levels of state-anxiety, future self-identification, academic self-efficacy, and perceived predictability. Part 2 of the study aims to test the efficacy of a web-based manipulation among a sample of first-year students at Arizona State University. The experimental manipulation utilizes elements of self-compassion to attempt to mitigate the effects of uncertainty and anxiety, and their negative effects on cognitive performance. Additionally, the manipulation aims to increase academic self-efficacy and future self-identification. The study was administered online and consisted of 170 participants. For part one of the study, all participants were used in the correlational analyses. For part two of the study, the participants were randomly divided into two groups, the control condition and the self-compassion condition. As hypothesized, findings show that uncertainty of one’s future predicted (a) higher state-anxiety, (b) weaker future self-identification(b) less perceived predictability of the future, and (c) less academic self-efficacy. Analysis also revealed that perceived uncertainty and anxiety predicted a higher level of cognitive interference as evidenced by the number of errors on the Stroop Task. Nevertheless, the proposed manipulation did not demonstrate statistically significant effects to reduce students’ perceived uncertainty and anxiety about their future. In conclusion, the present findings support the theorized relationships between uncertainty, anxiety, future self-identification, self-efficacy, and cognitive performance. Implications, limitations and future directions of this research are discussed.