Regolith excavation systems are the enabling technology that must be developed in order to implement many of the plans for in-situ resource utilization (ISRU) that have been developed in recent years to aid in creating a lasting human presence on the surface of the Moon, Mars, and other celestial bodies. The majority of proposed ISRU excavation systems are integrated onto a wheeled mobility system, however none yet have proposed the use of a screw-propelled vehicle, which has the potential to augment and enhance the capabilities of the excavation system. As a result, CASPER, a novel screw-propelled excavation rover is developed and analyzed to determine its effectiveness as a ISRU excavation system. The excavation rate, power, velocity, cost of transport, and a new parameter, excavation transport rate, are analyzed for various configurations of the vehicle through mobility and excavation tests performed in silica sand. The optimal configuration yielded a 28.4 kg/hr excavation rate and11.2 m/min traverse rate with an overall system mass of 3.4 kg and power draw of26.3 W. CASPER’s mobility and excavation performance results are compared to four notable proposed ISRU excavation systems of various types. The results indicate that this architecture shows promise as an ISRU excavator because it provides significant excavation capability with low mass and power requirements.