Peyote is a subject which renders the mechanisms, forces, and assemblages of colonialism clear. It is in the very inability of the colonial world to categorize, locate, understand and react to peyote that reveals so much about how colonialism operates. A primary goal of this project is to demonstrate that through understanding peyote, and its role in both colonial and contemporary history, one may come to better understand or recognize racial hierarchies and colonial forces which have not gone away with time. The first chapter is primarily a discussion of the Ghost Dance, I lay out some of the difficulties that indigenous appeals to religious freedom face both in terms of political power, but also conceptual, cultural, and academic thinking. In chapter two I move more specifically to the topic of peyote, tracing peyote’s history from precolonial times to the present. Chapters three and four deal with peyote as part of the borderlands and part of the War on Drugs respectively. I argue that understanding peyote can benefit a broader decolonial project within scholarship. The richness of the intersections between peyote and myriad other subjects is vastly understudied in academia and continued decolonial scholarship on the topic could have immense potential in bringing new insights into view. I draw heavily on scholars such as Edward Said and Aimé Césaire, but I have also been strongly influenced by other scholars such as Linda Tuhiwai Smith, Frantz Fanon, and Gloria Anzaldúa. In keeping with the decolonial mission, it is important to recognize that much of what I am presenting in this work is necessarily new or radical to the indigenous communities who are close to the topics at hand. While I present my own novel insights and discoveries, I also intend for this project to be a call for greater attention and study to be brought to the subject of peyote.