An important facet of daily memory function is prospective memory, which is one’s ability to complete established intentions in the appropriate temporal and spatial context. Many factors contribute to impairments in prospective memory, such as limited cognitive resources or aging. A factor that has been subject to recent investigation is how cannabis use may have an impact on the mechanisms that contribute to prospective memory. Cannabis use has been on the rise across the world, and in the United States more states are pushing to legalize its recreational use, if they haven’t already. As this substance becomes more easily accessible, akin to alcohol use, the necessity to investigate its potential consequences on cognition is needed now more than ever. Prospective memory is an appropriate measure of cannabis-induced deficits due to the wide literature looking at neural correlates of the component mechanisms that contribute to successful prospective memory, attentional and memory processes. The current study employed two experiments to measure this argued claim. Experiment 1 replicated well-defined effects from the prospective memory literature by measuring task accuracy (memory), response times (attention), and pupillary dynamics (attention). Informed by the research looking at the brain regions suspected of experiencing the most functional impairment, Experiment 2 aimed to extend these findings with a sample of participants following acute cannabis administration, however, results indicated cannabis group performance was similar in accuracy and showed faster mean latencies to that of the control group.

The emotional enhancement of memory (EEM) has consistently suggested that memory performance is enhanced for positively and negatively valenced stimuli. Heightened arousal and activation of the noradrenergic system facilitates encoding and the formation of memory traces. However, this EEM can become maladaptive when coupled with the heightened noradrenergic activity associated with posttraumatic stress disorder (PTSD). This heightened noradrenergic response can result in chronic intrusive memories of past traumatic events. This study aims to explore overall recall, retrieval dynamics, output editing, and intrusions as a function of emotional content and prior history with traumatic experiences. Undergraduate students (N=249) from Arizona State University completed a battery surveys measuring PTSD symptomatology and other related constructs including anxiety, depression, and trauma. Participants then completed a memory task, an externalized free recall task for multiple study-blocks utilizing word list stimuli. During recall, participants were instructed to report every word that came to mind regardless of whether it was present or not in the most recent study-block, then make a judgment about recent-list membership. Main effects of valence were found for recall accuracy, intrusion generation, and successful editing. This suggests that the emotional enhancement of memory does in fact play a role in intrusion generation and the ability to edit out false recollections. Only depression levels resulted in a significant interaction effect with valence, specifically when measuring intrusion generation. This suggests that trauma level does not play a significant role in emotional intrusion memory.

Sustained attention, the ability to concentrate on a stimulus or task over a prolonged period, is essential for goal pursuit and fulfillment. Sustained attention failures can have catastrophic consequences, underscoring the importance of understanding the mechanisms that underlie variability in sustained attention, and developing interventions targeting these mechanisms to reduce such failures. A growing body of research implicates the brainstem locus coeruleus (LC) as a core modulator of attention and arousal. Activation of LC afferents, such as the trigeminal nerve, may indirectly modulate the LC. The altered LC activity could theoretically be tracked via well-established psychological and physiological indicators of attention and arousal, such as performance, self-reports of attention state, and pupillary activity during attention tasks. The present study tests the hypothesis that continuous transcranial direct current stimulation (tDCS) over the trigeminal nerve of the face improves attentional state, attentional performance, and pupillary reactivity via indirect modulation of the LC. Participants received 2 mA of anodal or cathodal stimulation or sham stimulation over the dorsolateral prefrontal cortex while completing the Psychomotor Vigilance Task. Participants occasionally reported on their attentional state. Pupillary activity was recorded continuously throughout the task. To compare patterns of attention task performance, frequency of task-unrelated thoughts, and pupillary activity across time by stimulation condition, linear mixed-effects models were implemented. The results replicate the complex interplay between attentional state, attentional performance, and pupillary activity reported in the literature. Specifically, a ubiquitous pattern of performance deterioration was observed, which coincided with an increase in task-unrelated thoughts and reduced pretrial and task-evoked pupil responses. However, tDCS over the face did not produce significant effects compared to the sham condition in attention task performance, proportion of task-unrelated thoughts, and pupillary activity that would indicate LC modulation. This study addresses the causal relations between LC activity, attentional state, attentional performance, and pupillary reactivity that are still poorly understood in human subjects. The findings reported here support the dominant theory of the role of the LC in attentional processes but fail to support hypotheses suggesting that tDCS of the trigeminal nerve influences activity of the LC and indicators of LC activity.

Research has demonstrated observers have a generic bias for top saliency in object identification, such that random shapes appear more similar to ones that share the same tops versus same bottoms (Chambers et al., 1999). These findings are consistent with the idea that in nature, the tops of most important objects and living things tend to be the most informative locations with respect to intentionality and functionality, leading observers to favor attending to top. Yet, such a bias also may imply a generic downward vantage bias, suggesting that unlike natural objects, the more informative aspects of scenes tend to lie below their horizon midpoints. In two experiments, saliency bias was investigated for objects and scenes with both information-balanced and naturalistic stimuli. Experiment 1 replicates and extends the study of the top-saliency effect for information-balanced objects. Here 91 participants made 80 similarity judgments between an information-balanced object and two comparison objects that contain either the same top or the same bottom. Participants also made 80 similarity judgments of information-balanced scenes in which the coordinates of the vertices of the random shapes were replaced with little objects to create a scene. Experiment 2 extends Chambers et al. (1999) by examining top-saliency bias in naturalistic object perception when 91 participants made similarity judgments between a photographed test object and two comparison objects which contain either the same top or the same bottom. Experiment 2 also tests the idea of a downward vantage bias by predicting that naturalistic scenes will be judged more similar when the portions that lie below the horizon are identical versus when the portions above are the same. Results of the two experiments confirm that observers tend to assume a downward vantage when viewing pictures of objects and objects within scenes, which supports that saliency varies as a function of the informative aspect of the visually attended component.

Capacity limits of the human nervous system require important or rewarding information to be prioritized and encoded over less important or rewarding information. The present dissertation aims to identify structural and functional neural correlates of reward-motivated memory encoding. Chapter 1 reviews studies of reward-motivated memory encoding and their neural correlates, as well as the structure and function of dopaminergic midbrain circuits. Chapter 2 presents a study that utilizes electroencephalography (EEG) to determine which of two hypothesized processes underly the influence of reward value on episodic memory. One hypothesis is that value engages prefrontal executive control processes, so that valuable stimuli engage an elaborative rehearsal strategy that benefits memory. A second hypothesis is that value acts through the reward-related midbrain dopamine system to modulate synaptic plasticity in hippocampal and cortical efferents, thereby benefiting memory encoding. The results revealed that EEG signals thought to index dopamine-driven attention allocation were modulated by reward value and were positively correlated with individual differences in behavioral measures of memory prioritization. Chapter 3 employs diffusion-weighted magnetic resonance imaging (MRI) to dissociate heterogenous functional circuits of the midbrain reward system. The results comport with primate histology and show that midbrain circuits are differentially predictive of impulsivity and of attention-deficit hyperactivity disorder (ADHD). Chapter 4 presents a study that also employs diffusion-weighted MRI. The findings replicate Chapter 3 in dissociating heterogenous functional circuits of the midbrain reward system. Additionally, the structural integrity of midbrain-hippocampus circuits was quantified. Structural integrity of these circuits was positively correlated to behavioral measures of memory prioritization. These findings suggest that structural and functional measures of the dopaminergic reward system may underlie reward-motivated memory encoding in humans.

Humans are biased toward teleological explanations of natural phenomena. The promiscuous teleology account posits that this proclivity is rooted in the detection of supernatural agency behind the design of the natural world. This idea is supported by numerous positive correlations of religious belief and agreement with teleological explanations of natural phenomena, but it is challenged by findings that non-believers often agree with them as well, suggesting the need for an adjudicating experiment. The current experiment tested whether considering similar teleological explanations of nature causes explicitly theistic and atheistic people to think about God, which would suggest that the teleological bias has roots in agency detection. Participants (N = 608) were randomly assigned to consider teleological explanations of either human-caused phenomena or natural phenomena, with the main prediction that considering the natural item set would make theists relatively faster to categorize God as real but make atheists relatively slower to categorize God as imaginary. The data did support this hypothesis, suggesting that people across the theistic belief spectrum automatically think of God when thinking about nature’s purpose, and thus the teleological bias might be rooted in the detection of supernatural agency. Implications for theories of teleology, study limitations, and potential future directions are discussed.

Individuals encounter problems daily wherein varying numbers of constraints require delimitation of memory to target goal-satisfying information. Multiply-constrained problems, such as compound remote associates, are commonly used to study this type of problem solving. Since their development, multiply-constrained problems have been theoretically and empirically related to creative thinking, analytical problem solving, insight problem solving, intelligence, and a multitude of other cognitive abilities. Critically, in order to correctly solve a multiply-constrained problem the solver must have the solution available in memory and be able to target and access to that information. Experiment 1 determined that the cue – target relationship affects the likelihood that a problem is solved. Moreover, Experiment 2 identified that the association between cues and targets predicted inter- & intra-individual differences in multiply-constrained problem solving. Lastly, Experiment 3 found monetary incentives failed to improve problem solving performance likely due to knowledge serving as a limiting factor on performance. Additionally, problem solvers were shown to be able to reliably assess the likelihood they would solve a problem. Taken together all three studies demonstrated the importance of knowledge & knowledge structures on problem solving performance.