Depression has been found to be a major problem for young adults in college, with multiple studies indicating high prevalence rates for this population. College students struggling with depression suffer from various consequences, including academic impairment and suicidal ideation, with suicide being a leading cause of death for people in the typical age range for undergraduates. Grounded in cognitive behavior theory and humanistic theory, this study examined the intra and interpersonal factors related to depression among undergraduates. Specifically, the interrelations between friend social support, sense of belonging to the college, mattering to friends, hope, and depressive symptoms were explored. Sex and number of close friends were controlled for, as the literature also showed evidence of their significant relations to depression. The sample consisted of 177 undergraduates between the ages of 18 and 25 from a large southwestern university. Participants responded to an online survey. While participants represented a diverse range of ethnicities, the majority were White. Hierarchical multiple regression analyses revealed that hope and sense of belonging to the college negatively predicted depressive symptoms. Furthermore, through zero-order correlations, it was found that friend social support, sense of belonging to the college, mattering to friends, and hope were all positively correlated with each other. Implications for prevention and clinical practice include the roles that counselors, college personnel, and students play in the battle against depression.