The utilization of multimedia videos has increasingly become more popular, especially in the field of education. In order to facilitate learning it is important to create a natural interaction between the learner and the on-screen material. This study focused on improving the facilitation of the information within a multimedia learning video by focusing on the gender and quality of computer-synthesized voices. Using a randomized pretest - posttest design the study looked at how the gender of the narrator affected a person's ability to learn and implement a new task. Narration was performed by a male and female, classic and modern synthesized voices to determine if there were gender effects across both generations of voices. The participants’ learned knowledge was assessed through a multiple-choice assessment and a word to image matching transfer assessment. Results showed no significant results. Future studies should consider a more reliable knowledge assessment and utilize and larger sample size.