The Universe transitioned from a state of neutral hydrogen (HI) shortly after recombination to its present day ionized state, but this transition, the Epoch of Reionization (EoR), has been poorly constrained by observational data. Estimates place the EoR between redshifts 6 < z <13 (330-770 Myr).

The interaction of the 21 cm hyperfine ground state emission/absorption-line of HI with the cosmic microwave background (CMB) and the radiation from the first luminous sources in the universe can be used to extract cosmological information about the EoR. Theorists have created global redshifted 21 cm EoR models of this interaction that predict the temperature perturbations to the CMB in the form of a sky-averaged difference temperature, Tb. The difficulty in measuring Tb is that it is

predicted to be on the order of 20 to 100 mK, while the sky foreground is dominated

by synchrotron radiation that is 105 times brighter. The challenge is to subtract the much brighter foreground radiation without subtracting the Tb signal and can only be done when the data has small error levels.

The Experiment to Detect the Global EoR Signature (EDGES) is an effort to measure Tb with a single wide field-of-view well-calibrated antenna. This dissertation focuses on reducing systematic errors by quantifying the impact of the chromatic nature of the antenna’s beam directivity and by measuring the variability of the spectral index of the radio sky foreground. The chromatic beam study quantified the superior qualities of the rectangular blade-shaped antenna and led to its adoption over the previously used fourpoint-shaped antenna and determined that a 5 term polynomial was optimum for removing the foreground. The spectral index, β, of the sky was measured, using 211 nights of data, to be −2.60 > β > −2.62 in lower LST regions, increasing to −2.50 near the Galactic plane. This matched simulated results using the Guzm´an et al. (2011) sky map (∆β < 0.05) and demonstrated the exceptional stability of the EDGES instrument. Lastly, an EoR model by Kaurov & Gnedin (2016) was shown to be inconsistent with measured EDGES data at a significance level of 1.9.