The relation of stigma to help-seeking attitudes and intentions and how these relations differed across cultures for American students, East Asian, and South Asian international students, were the focus of this study. Previous researchers had found that not seeking professional psychological help when needed was prevalent for both American and international students. Stigma has been found to be a salient factor in influencing attitudes of individuals and may prevent individuals from getting the help they need. Both public and self-stigma were utilized to predict attitudes and intentions to seek psychological help in a sample of 806 students. Structural equation modeling analyses were conducted to assess the relationships in how self-stigma, public stigma, attitudes toward counseling and intentions to seek counseling will interplay for American, East Asian and South Asian international students, further expanding on previous help-seeking model (Vogel et al., 2007). Results indicated differences in factor structure of scales for the groups, and new factors were identified. With the new factors derived, different models of help-seeking intentions were established for each group, and distinct relations among the factors were explained. Furthermore, implications for future studies and clinical relevance were highlighted.