Hospitalized and chronically ill infants are at risk for motor, cognitive, and social developmental delays. Nurses have an important role in supporting infant and family development to mitigate these delays. A literature review was performed to identify nursing interventions that promote development in these three categories. After literature was selected, critical appraisals were performed to assess the quality of evidence. Breast feeding, early cognitive-motor intervention, and family centered care were found to be beneficial for promoting motor development. Maternal scaffolding, responsive-didactic caregiving, and skin-to-skin contact are recommended nursing interventions for cognitive development. Lastly, integration of music is the nursing intervention recommended to promote social development.