Description
Dementia is a disease affecting many individuals worldwide resulting in neurological deficits. The most common form of dementia known as Alzheimer’s Disease (AD) is the 6th leading cause of death in the United States. The disease is defined by neuron loss, the presence of intracellular tau protein (tubulin associated unit) neurofibrillary tangles (NFT), and extracellular amyloid- (Aβ) plaques. For this study, our aim was to understand the staging system used based off of the disease progression, called Braak Staging. Our hypothesis is that as disease progresses, marked by Braak stages, different brain regions will begin to show differential expressions of various biological dysregulations. Molecular dysfunctions of early disease will be precursors to later disease dysfunctions. The outcomes of our study indicated there were several molecular dysfunctions in early disease with tau pathology not present in the region yet.
Details
Title
- Utilizing Braak staging to detect early brain region specific molecular process dysfunction in Alzheimer’s disease
Contributors
- Mirji, Ruchira (Author)
- Huseby, Carol (Thesis director)
- Velazquez, Ramon (Committee member)
- Barrett, The Honors College (Contributor)
- School of Life Sciences (Contributor)
- School of Human Evolution & Social Change (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2024-05
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