Description
An immune regulatory network was constructed for the purpose of identifying target regulators in malignant pleural mesothelioma for therapies. An identified causal flow linked a mutation of D-dopachrome tautomerase to a heightened expression of regulator ASH1L and consequent down regulation of chemokine CCL5 and invasion of CD8+ T cells. Experimental validation of this initial use case indicates mRNA expression of CCL5 within the tumor cells and subsequent protein expression and secretion. Further analyses will explore the migration of CD8+ T cells in response to the chemotactic CCL5.
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Details
Title
- Applying Regulatory Networks to the Immune Landscape of Mesothelioma
Contributors
- Cook, Margaret (Author)
- Plaisier, Christopher (Thesis director, Committee member)
- Wilson, Melissa (Committee member)
- Barrett, The Honors College (Contributor)
- Harrington Bioengineering Program (Contributor)
- School of Molecular Sciences (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2022-05
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