Description
Latino youth have substantially higher rates of obesity and T2D than their white peers. The higher prevalence of obesity and T2D among Latino youth places them at greater risk for cognitive dysfunction, an urgent and serious health threat to the United States. Exercise has been the cornerstone to combat the negative effects of obesity, diabetes and recent research also supports this effects for preventing cognitive dysfunction. A wealth of evidence suggests that a mediating mechanism linking exercise with brain health is BDNF, a cognitive biomarker that increases in the brain with exercise. BDNF is the most abundant neurotrophic factor that supports growth, survival and synaptic plasticity of neurons, all vital for cognitive function and brain health. The present study sought to investigate the effects of a 12-week lifestyle intervention of physical activity and lifestyle education on serum BDNF, in obese pre diabetic Latino youth.
A total of twelve obese pre diabetic Latino youth were selected from a larger RCT sample to be the focus for this analysis. After an overnight fast, a serum concentration was collected from all youth to be used for the BDNF analysis. In addition, the following cardio metabolic measures were also at taken at baseline and post intervention: Submaximal VO2max, medical and family history questionnaire, anthropometric, fasting glucose and a 2-hour oral glucose tolerance test (OGTT). A 12-weeks Lifestyle Intervention that involved a progressive moderate to high intensity exercise component and lifestyle education program did not significantly change serum BDNF levels in obese pre diabetic Latino youth. In conclusion, the variation of our serum BDNF results are highly speculative at this time, therefore the need for future investigations is crucial.
A total of twelve obese pre diabetic Latino youth were selected from a larger RCT sample to be the focus for this analysis. After an overnight fast, a serum concentration was collected from all youth to be used for the BDNF analysis. In addition, the following cardio metabolic measures were also at taken at baseline and post intervention: Submaximal VO2max, medical and family history questionnaire, anthropometric, fasting glucose and a 2-hour oral glucose tolerance test (OGTT). A 12-weeks Lifestyle Intervention that involved a progressive moderate to high intensity exercise component and lifestyle education program did not significantly change serum BDNF levels in obese pre diabetic Latino youth. In conclusion, the variation of our serum BDNF results are highly speculative at this time, therefore the need for future investigations is crucial.
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Details
Title
- Effects of a lifestyle intervention on brain-derived neurotrophic factor (BDNF) in obese Latino youth with pre-diabetes
Contributors
- Barraza, Estela (Author)
- Shaibi, Gabriel Q. (Thesis advisor)
- Swan, Pamela (Committee member)
- Nanez, Jose E (Committee member)
- Arizona State University (Publisher)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2016
Subjects
- Health Sciences
- Neurosciences
- psychology
- BDNF
- Cognitive Function
- Exercise
- Latino Youth
- Lifestyle Intervention
- Prediabetic
- Biochemical markers
- Health Promotion
- Diabetes in adolescence
- Exercise--Physiological aspects.
- Hispanic American youth--Health and hygiene.
- Hispanic American youth
- Overweight teenagers--Health and hygiene.
- Overweight teenagers
Resource Type
Collections this item is in
Note
- thesisPartial requirement for: M.S., Arizona State University, 2016
- bibliographyIncludes bibliographical references (pages 33-44)
- Field of study: Excercise and wellness
Citation and reuse
Statement of Responsibility
by Estela Barraza