137802-Thumbnail Image.png
Description
Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies

Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer patients were used to discover these tumor associated biomarkers on protein microarrays. Six candidate biomarkers were discovered from 22 heavy chain-only variable region antibody fragments screened. Validation tests are necessary to confirm the tumorgenicity of these antigens. However, the use of single-chain variable autoantibody fragments presents a novel platform for diagnostics and cancer therapeutics.
958.3 KB application/pdf

Download restricted. Please sign in.
Restrictions Statement

Barrett Honors College theses and creative projects are restricted to ASU community members.

Details

Title
  • Identification of Tumor Associated Antigens using Nucleic Acid Programmable Protein Arrays
Contributors
Date Created
2012-12
Resource Type
  • Text
  • Machine-readable links