Description
Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer patients were used to discover these tumor associated biomarkers on protein microarrays. Six candidate biomarkers were discovered from 22 heavy chain-only variable region antibody fragments screened. Validation tests are necessary to confirm the tumorgenicity of these antigens. However, the use of single-chain variable autoantibody fragments presents a novel platform for diagnostics and cancer therapeutics.
Details
Title
- Identification of Tumor Associated Antigens using Nucleic Acid Programmable Protein Arrays
Contributors
- Sharman, M. Camila (Author)
- Magee, Dewey (Mitch) (Thesis director)
- Wallstrom, Garrick (Committee member)
- Petritis, Brianne (Committee member)
- Barrett, The Honors College (Contributor)
- College of Liberal Arts and Sciences (Contributor)
- Virginia G. Piper Center for Personalized Diagnostics (Contributor)
- Biodesign Institute (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2012-12
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