Description
Recent efforts have attempted to describe the population structure of common chimpanzee, focusing on four subspecies: Pan troglodytes verus, P. t. ellioti, P. t. troglodytes, and P. t. schweinfurthii. However, few studies have pursued the effects of natural selection in shaping their response to pathogens and reproduction. Whey acidic protein (WAP) four-disulfide core domain (WFDC) genes and neighboring semenogelin (SEMG) genes encode proteins with combined roles in immunity and fertility. They display a strikingly high rate of amino acid replacement (dN/dS), indicative of adaptive pressures during primate evolution. In human populations, three signals of selection at the WFDC locus were described, possibly influencing the proteolytic profile and antimicrobial activities of the male reproductive tract. To evaluate the patterns of genomic variation and selection at the WFDC locus in chimpanzees, we sequenced 17 WFDC genes and 47 autosomal pseudogenes in 68 chimpanzees (15 P. t. troglodytes, 22 P. t. verus, and 31 P. t. ellioti). We found a clear differentiation of P. t. verus and estimated the divergence of P. t. troglodytes and P. t. ellioti subspecies in 0.173 Myr; further, at the WFDC locus we identified a signature of strong selective constraints common to the three subspecies in WFDC6—a recent paralog of the epididymal protease inhibitor EPPIN. Overall, chimpanzees and humans do not display similar footprints of selection across the WFDC locus, possibly due to different selective pressures between the two species related to immune response and reproductive biology.
Details
Title
- Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity
Contributors
- Ferreira, Zelia (Author)
- Hurle, Belen (Author)
- Andres, Aida M. (Author)
- Kretzschmar, Warren W. (Author)
- Mullikin, James C. (Author)
- Cherukuri, Praveen F. (Author)
- Cruz, Pedro (Author)
- Gonder, Mary Katherine (Author)
- Stone, Anne (Author)
- Tishkoff, Sarah (Author)
- Swanson, Willie J. (Author)
- Green, Eric D. (Author)
- Clark, Andrew G. (Author)
- Seixas, Susana (Author)
- NISC Comparative Sequencing Program (Author)
- College of Liberal Arts and Sciences (Contributor)
- School of Human Evolution and Social Change (Contributor)
- School of Life Sciences (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2013-12-19
Resource Type
Collections this item is in
Identifier
- Digital object identifier: 10.1093/gbe/evt198
- Identifier TypeInternational standard serial numberIdentifier Value1759-6653
Note
- The final version of this article, as published in Genome Biology and Evolution, can be viewed online at: https://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evt198
Citation and reuse
Cite this item
This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.
Ferreira, Z., Hurle, B., Andrés, A. M., Kretzschmar, W. W., Mullikin, J. C., Cherukuri, P. F., . . . Seixas, S. (2013). Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity. Genome Biology and Evolution, 5(12), 2512-2523. doi:10.1093/gbe/evt198