128935-Thumbnail Image.png

Background: We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person’s fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer’s disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is…

Background: We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person’s fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer’s disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.

Methods: An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.

Results: These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).

Conclusions: The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.

Copyright Statement
    • Reuse Permissions
    • Downloads
    PDF (231.6 KB)

    Details

    Title
    • Association Between an Alzheimer’s Disease-Related Index and APOE ε4 Gene Dose
    Contributors
    Date Created
    2013-06-26
    Resource Type
  • Text
    • Collections this item is in
    ASU Scholarship Showcase
    Identifier
    • Digital object identifier: 10.1371/journal.pone.0067163
    • International standard serial number
      1045-3830
    • International standard serial number
      1939-1560
    Note
    • The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067163

    Citation and reuse

    Cite this item

    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Schraml, F., Chen, K., Ayutyanont, N., Auttawut, R., Langbaum, J. B., Lee, W., . . . Reiman, E. M. (2013). Association between an Alzheimer’s Disease-Related Index and APOE ε4 Gene Dose. PLoS ONE, 8(6). doi:10.1371/journal.pone.0067163

    Machine-readable links