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EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them.

EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers.

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    Title
    • EMT and Tumor Metastasis
    Contributors
    Date Created
    2015-02-26
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1186/s40169-015-0048-3
    • Identifier Type
      International standard serial number
      Identifier Value
      2001-1326
    Note
    • The electronic version of this article is the complete one and can be found online at: http://clintransmed.springeropen.com/articles/10.1186/s40169-015-0048-3

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    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Heerboth, S., Housman, G., Leary, M., Longacre, M., Byler, S., Lapinska, K., . . . Sarkar, S. (2015). EMT and tumor metastasis. Clinical and Translational Medicine, 4(1). doi:10.1186/s40169-015-0048-3

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