Down syndrome (DS), which is determined by an extra 21 chromosome, is one of the most common developmental disabilities across all races and societies. One of the hallmarks of people with DS is that they have deficits in cognitive control compared with their peers. In addition to broad cognitive impairment, persons with DS have physical characteristics which limit their ability to perform activities of daily living (ADL) including deficits in fine motor control needed for handling money, self-care, eating, etc. As the relative prevalence of DS at birth lessens, and as life expectancy increases, DS will be most commonly represented amongst the elderly. Thus, intervention is needed in older adults with DS to improve their manual dexterity to sustain their independence and quality of life. The aim of this study was to examine the influence of Assisted Cycling Therapy (ACT) compared to voluntary cycling (VC) and no cycling (NC) on fine motor control in older adults with Down Syndrome (DS). Twenty-five older adults with DS were randomly assigned to one of three, 30 minute interventions, which took place over an eight-week period of time. 1) Thirteen older adults with DS completed the ACT intervention, which is stationary cycling with the assistance of a motor to maintain a cadence at least 35% greater than voluntary cycling. 2) Ten older adults with DS completed voluntary cycling (VC) and 3) Two older adults with DS were in our no cycling (NC) intervention. Fine motor control was measured with the Purdue Pegboard placing pegs in small holes in 30 s with the right hand alone, the left hand alone, and bimanually pre and post 8 weeks of intervention. Our results showed that bimanual and total score (i.e., right, left and bimanually) fine motor control improved following both ACT and VC cycling exercise but not NC. This suggests that 30 minutes of exercise over 8 weeks has some positive effects on manual dexterity. Different mechanisms for this improvement will be discussed. This information is important to the independence and quality of life of older adults with DS.