This dissertation is an examination of a modernist desire to construct future materiality via material language, which represents a desire to overcome biology and the biological body. As such, modernist discourses of material language must be understood within their broader historical context, as these textual constructs developed against a cultural backdrop replete with eugenicist ideologies. Modernists wielded discourses of material language to determine via cultural reproduction which futures might materialize, as well as which bodies could occupy those futures and in what capacities. This dissertation argues that these modernist constructs contain their own failure in their antibiologism and their refusal to acknowledge the agency of corporeal materiality before them. Unlike language, the body expresses biopower through its material (re)productivity—its corpo-reality—which, though it can be shaped and repressed by discourse, persistently ruptures through the restraints of eugenicist ideologies and the autonomous liberal model of white masculine embodiment they uphold. This work analyses sexually marginalized bodies in texts by Mina Loy, Djuna Barnes, Nathanael West, and Ernest Hemingway that, through their insistently persistent biological materiality, disrupt modernist discourses of material language that offer no future for feminine, queer, and disabled corporeality. By exploring how intersecting issues of gender, sexuality, and disability complicate theories of language’s materiality in modern American literature, this dissertation brings attention to writers and texts that challenge broader attempts in the early decades of the twentieth century to subvert the biological body through eugenicist projects of cultural reproduction.