Full metadata
Title
Indoxyl Sulfate and Autism Spectrum Disorder: A Literature Review
Description
Autism Spectrum Disorder (ASD) is an intricate neurodevelopmental disorder characterized by impaired social functioning and communication, repetitive behavioral patterns, and specialized interests (Olesova et al., 2020; Osredkar et al., 2023). Despite the efforts of modern science, the biological origin of ASD is unknown, and no known biomarker for ASD currently exists (Olesova et al., 2020; Osredkar et al., 2023). Indoxyl sulfate has been identified as a toxin associated with ASD and its related symptomology in addition to a number of other conditions, including chronic kidney disease, acute kidney injury, heart failure, Parkinson’s disease, and various mood disorders (Cao et al., 2015; Cassani et al., 2015; Karbowska et al., 2020; Zhao et al., 2013). This article will review what is currently known about indoxyl sulfate in relation to ASD and its comorbidities in an attempt to determine the validity of indoxyl sulfate as a potential biomarker for ASD. Articles for the purposes of this review were collected via Google Scholar, PubMed, and the ASU Library using key words such as “indoxyl sulfate,” “Autism,” and “indican,” and chosen based on relevancy. Through this review, indoxyl sulfate was identified as a potential physiological biomarker for a subset of ASD, with additional research required to verify the findings presented. The identification of a biomarker for ASD could change the current methods of testing for ASD, greatly improving our understanding and treatment of the disorder.
Date Created
2024-05
Contributors
- Hill, Zoë (Author)
- Adams, James (Thesis director)
- Flynn, Christina (Committee member)
- Barrett, The Honors College (Contributor)
- College of Health Solutions (Contributor)
- Edson College of Nursing and Health Innovation (Contributor)
Topical Subject
Resource Type
Extent
29 pages
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Series
Academic Year 2023-2024
Handle
https://hdl.handle.net/2286/R.2.N.192099
System Created
- 2024-04-06 01:07:24
System Modified
- 2024-04-08 01:09:11
- 7 months 2 weeks ago
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