Full metadata
Title
Characterizing and Releasing Biological Constraints for Lignocellulosic Bioconversion
Description
Lignocellulose, the major structural component of plant biomass, represents arenewable substrate of enormous biotechnological value. Microbial production of
chemicals from lignocellulosic biomass is an attractive alternative to chemical synthesis.
However, to create industrially competitive strains to efficiently convert lignocellulose to
high-value chemicals, current challenges must be addressed. Redox constraints, allosteric
regulation, and transport-related limitations are important bottlenecks limiting the
commercial production of renewable chemicals from lignocellulose. Advances in
metabolic engineering techniques have enabled researchers to engineer microbial strains
that overcome some of these challenges but new approaches that facilitate the
commercial viability of lignocellulose valorization are needed. Biological systems are
complex with a plethora of regulatory systems that must be carefully modulated to
efficiently produce and excrete the desired metabolites. In this work, I explore metabolic
engineering strategies to address some of the biological constraints limiting
bioproduction such as redox, allosteric, and transport constraints to facilitate cost-effective
lignocellulose bioconversion.
Date Created
2023
Contributors
- Onyeabor, Moses Ekenedilichukwu (Author)
- Wang, Xuan (Thesis advisor)
- Varman, Arul M (Committee member)
- Nannenga, Brent (Committee member)
- Nielsen, David R (Committee member)
- Geiler-Samerotte, Kerry (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
279 pages
Language
eng
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.2.N.187561
Level of coding
minimal
Cataloging Standards
Note
Partial requirement for: Ph.D., Arizona State University, 2023
Field of study: Microbiology
System Created
- 2023-06-07 11:38:49
System Modified
- 2023-06-07 11:38:55
- 1 year 5 months ago
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