Full metadata
Title
Understanding Rectum and Ileum Microbiome Composition and Clinical Variable Association with Multiview Microbiome Data in Inflammatory Bowel Diseases
Description
Microbial diversity manifests differently in different ecological niches of the body, with greater diversity generally expected in the gut, given that different locations have unique roles to play in the digestive system. Most microbial research is conducted using fecal samples, meaning the resulting microbes come from various places all throughout the intestines and not specific locations. The Integrative Human Microbiome Project (HMP2), provides a unique opportunity to study microbiomes of both the rectum and ileum through the use of biopsy samples taken from both locations. Using the data provided the microbiome compositions of the rectum and ileum were able to be studied and analyzed to showcase how those microbes associated with clinical variables. Inflammatory bowel diseases are complex diseases that are heterogeneous at clinical, immunological, molecular, genetic, and microbial levels. While it is known that those affected by these diseases have microbiomes that differ from those with healthy guts, not much is known about which changes in the microbiome represent causes rather than effects from changes in health.
Date Created
2023
Contributors
- Vecchio, Kurt (Author)
- Zhao, Yunpeng (Thesis advisor)
- Wang, Yue (Committee member)
- Jurutka, Peter (Committee member)
- Arizona State University (Publisher)
Topical Subject
Resource Type
Extent
40 pages
Language
Copyright Statement
In Copyright
Primary Member of
Peer-reviewed
No
Open Access
No
Handle
https://hdl.handle.net/2286/R.2.N.187410
Level of coding
minimal
Cataloging Standards
Note
Partial requirement for: M.S., Arizona State University, 2023
Field of study: Natural Science
System Created
- 2023-06-06 07:33:32
System Modified
- 2023-06-06 07:33:36
- 1 year 3 months ago
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